About: Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)

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About: Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR) Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In 2008, the World Health Organization (WHO) revised its classification of hematopoietic neoplasms and new %22acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)%22 was defined as !AML arising from a previous MDS or MDS/MPN, AML with an MDS-related cytogenetic abnormality, and/or AML-MLD changes, mainly with a complex karyotype! (1). Myelodyplastic syndrome (MDS)-related chromosomal changes involve mainly aberrations of chromosomes 5, 7, and a complex karyotype. The change from ploidy to tetraploidy (4n) is a rare chromosomal abnormality in AML, and only a few cases have been described in the literature (2,3). Despite its rarity in AML, tetraploidization can initiate chromosomal instability (CIN) and promote cell transformation (4,5). Presented here is a case of a 52-year-old male with an initial diagnosis of AML-MRC with tetraploid clones detected in his bone marrow. FISH analysis revealed a large deleted derivative chromosome 5 within a complex caryotype. To the best of our knowledge, such findings in AML-MRC have not yet been reported in the literature. In 2008, the World Health Organization (WHO) revised its classification of hematopoietic neoplasms and new %22acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)%22 was defined as !AML arising from a previous MDS or MDS/MPN, AML with an MDS-related cytogenetic abnormality, and/or AML-MLD changes, mainly with a complex karyotype! (1). Myelodyplastic syndrome (MDS)-related chromosomal changes involve mainly aberrations of chromosomes 5, 7, and a complex karyotype. The change from ploidy to tetraploidy (4n) is a rare chromosomal abnormality in AML, and only a few cases have been described in the literature (2,3). Despite its rarity in AML, tetraploidization can initiate chromosomal instability (CIN) and promote cell transformation (4,5). Presented here is a case of a 52-year-old male with an initial diagnosis of AML-MRC with tetraploid clones detected in his bone marrow. FISH analysis revealed a large deleted derivative chromosome 5 within a complex caryotype. To the best of our knowledge, such findings in AML-MRC have not yet been reported in the literature. (en)
Title	Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR) Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR) (en)
skos:prefLabel	Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR) Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR) (en)
skos:notation	RIV/61989592:15110/12:33138480!RIV13-MSM-15110___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM6198959205)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	PAPAJÍK, Tomáš INDRÁK, Karel Jarošová, Marie Katrincsáková, Beáta Hubáček, Jaromír Pikalová, Zuzana Holzerová, Milena Nedomová, Radka Mičková, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	164118
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/12:33138480
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	FISH analysis; chromosomal changes; myelodysplastic syndrome (en)
http://linked.open.../riv/klicoveSlovo	chromosomal changes FISH analysis myelodysplastic syndrome
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A07EE1E9731C]
http://linked.open...i/riv/nazevZdroje	Leukemia Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	36
http://linked.open...iv/tvurceVysledku	Hubáček, Jaromír Indrák, Karel Jarošová, Marie Katrincsáková, Beáta Pikalová, Zuzana Papajík, Tomáš Holzerová, Milena Nedomová, Radka Mičková, Pavla
http://linked.open...n/vavai/riv/zamer	Studies of genes and molecular mechanisms involved in regulation of hematopoiesis, their clinical impact and targeted treatment
issn	0145-2126
number of pages	3 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.leukres.2011.12.014
http://localhost/t...ganizacniJednotka	15110

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