About: High baseline serum thymidine kinase 1 level predict unfavorable outcome in patients with folicular lymphoma

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About: High baseline serum thymidine kinase 1 level predict unfavorable outcome in patients with folicular lymphoma Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Abstract Serum thymidine kinase 1 (TK1) is a sensitive marker of tumor cell proliferation. TK1 was reported as a reliable prognostic factor in solid tumors and chronic lymphocytic leukemia, but has not been tested in large populations of non-Hodgkin lymphoma patients yet. In this study, a prognostic significance of TK1 levels was assessed in 170 prospectively enrolled patients with previously untreated follicular lymphoma. The TK1 level at the time of treatment initiation was shown to correlate with the clinical stage, FLIPI score, beta-2 microglobulin level, lactate-dehydrogenase level and B symptoms. No correlation was found with the FL grade or Ki-67 proliferative index. The Cox regression analysis identified high TK1 levels (?15 IU/L) as a prognostic factor for overall survival (hazard ratio 2.91, p=0.019) and progression-free survival (hazard ratio 1.94, p=0.022) independent of FLIPI score variables. Thus, TK1 levels may help refine risk assessment in the modern immunotherapy era. Abstract Serum thymidine kinase 1 (TK1) is a sensitive marker of tumor cell proliferation. TK1 was reported as a reliable prognostic factor in solid tumors and chronic lymphocytic leukemia, but has not been tested in large populations of non-Hodgkin lymphoma patients yet. In this study, a prognostic significance of TK1 levels was assessed in 170 prospectively enrolled patients with previously untreated follicular lymphoma. The TK1 level at the time of treatment initiation was shown to correlate with the clinical stage, FLIPI score, beta-2 microglobulin level, lactate-dehydrogenase level and B symptoms. No correlation was found with the FL grade or Ki-67 proliferative index. The Cox regression analysis identified high TK1 levels (?15 IU/L) as a prognostic factor for overall survival (hazard ratio 2.91, p=0.019) and progression-free survival (hazard ratio 1.94, p=0.022) independent of FLIPI score variables. Thus, TK1 levels may help refine risk assessment in the modern immunotherapy era. (en)
Title	High baseline serum thymidine kinase 1 level predict unfavorable outcome in patients with folicular lymphoma High baseline serum thymidine kinase 1 level predict unfavorable outcome in patients with folicular lymphoma (en)
skos:prefLabel	High baseline serum thymidine kinase 1 level predict unfavorable outcome in patients with folicular lymphoma High baseline serum thymidine kinase 1 level predict unfavorable outcome in patients with folicular lymphoma (en)
skos:notation	RIV/61989592:15110/12:33117919!RIV13-MSM-15110___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM6198959205)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Raida, Luděk Langová, Kateřina PAPAJÍK, Tomáš Faber, Edgar INDRÁK, Karel Procházka, Vít
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	138916
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/12:33117919
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	prognosis; CA-125; autologous transplantation; chemotherapy; Follicular lymphoma (en)
http://linked.open.../riv/klicoveSlovo	Follicular lymphoma autologous transplantation CA-125 chemotherapy prognosis
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[97C7ABEE5DA6]
http://linked.open...i/riv/nazevZdroje	Leukemia & Lymphoma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	53
http://linked.open...iv/tvurceVysledku	Faber, Edgar Indrák, Karel Langová, Kateřina Raida, Luděk Procházka, Vít Papajík, Tomáš
http://linked.open...n/vavai/riv/zamer	Studies of genes and molecular mechanisms involved in regulation of hematopoiesis, their clinical impact and targeted treatment
issn	1042-8194
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.3109/10428194.2011.654339
http://localhost/t...ganizacniJednotka	15110

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