About: MicroRNAs: emerging regulators of immune-mediated diseases

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MicroRNAs (miRNAs) represent the most abundant class of regulators of gene expression in humans: they regulate one third of human protein-coding genes. These small non-coding ?22 nucleotides (nt) long RNAs originate by multistep process from miRNA genes localized in the genomic DNA. To date, more than 1420 miRNAs have been identified in humans (miRBase v17). The main mechanism of miRNA action is the posttranscriptional regulation via RNA interference with their target mRNAs. The majority of target mRNAs (more than 80%) undergo degradation after recognition by complementary miRNA; the translational inhibition with little or no influence on mRNA levels has been also reported. Each miRNA may suppress multiple mRNA targets (average ?200) and at the same time one mRNA can be targeted by many miRNAs enables to control a spectrum wide range of cellular processes. MicroRNAs (miRNAs) represent the most abundant class of regulators of gene expression in humans: they regulate one third of human protein-coding genes. These small non-coding ?22 nucleotides (nt) long RNAs originate by multistep process from miRNA genes localized in the genomic DNA. To date, more than 1420 miRNAs have been identified in humans (miRBase v17). The main mechanism of miRNA action is the posttranscriptional regulation via RNA interference with their target mRNAs. The majority of target mRNAs (more than 80%) undergo degradation after recognition by complementary miRNA; the translational inhibition with little or no influence on mRNA levels has been also reported. Each miRNA may suppress multiple mRNA targets (average ?200) and at the same time one mRNA can be targeted by many miRNAs enables to control a spectrum wide range of cellular processes. (en)
Title	MicroRNAs: emerging regulators of immune-mediated diseases MicroRNAs: emerging regulators of immune-mediated diseases (en)
skos:prefLabel	MicroRNAs: emerging regulators of immune-mediated diseases MicroRNAs: emerging regulators of immune-mediated diseases (en)
skos:notation	RIV/61989592:15110/12:10224750!RIV13-MZ0-15110___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED0030/01/01), P(NT11049), P(NT11117), S
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Petřek, Martin Gallo, Jiří Tománková, Tereza Kriegová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	150383
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/12:10224750
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	autoimmune disorders; immune system disorders; inflammation; miRNA (en)
http://linked.open.../riv/klicoveSlovo	autoimmune disorders inflammation immune system disorders miRNA
http://linked.open...odStatuVydavatele	NO - Norské království
http://linked.open...ontrolniKodProRIV	[E78916A758AD]
http://linked.open...i/riv/nazevZdroje	Scandinavian Journal of Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of mediators of fibrotic processes in patients with diffuse lung diseases and their clinical application Biomedicine for regional development and human resources Gene expression profiling of the periprosthetic tissues: first step toward time-dependent analysis of periprosthetic osteolysis
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	75
http://linked.open...iv/tvurceVysledku	Gallo, Jiří Kriegová, Eva Petřek, Martin Tománková, Tereza
issn	1365-3083
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1365-3083.2011.02650.x
http://localhost/t...ganizacniJednotka	15110

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