About: Protocol biopsy of a transplanted kidney as a tool for monitoring adequacy of immunosupressive therapy: 10 years of experience from a single transplant center

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aims of this prospective study were to determine the prevalence of clinically silent rejection changes and of nephrotoxicity of calcineurin inhibitors among repeated protocol biopsies of transplanted kidneys and to assess their impacts on chronic graft function and damage at the end of 1 year. Subclinical rejection and toxic changes among a significant proportion of grafts are associated with progression of chronic changes already over the first year following transplantation. Hence they represent independent risk factors for the development of irreversible graft damage. Protocol biopsy seems to be an important method to monitor immunosuppressive therapy. The aims of this prospective study were to determine the prevalence of clinically silent rejection changes and of nephrotoxicity of calcineurin inhibitors among repeated protocol biopsies of transplanted kidneys and to assess their impacts on chronic graft function and damage at the end of 1 year. Subclinical rejection and toxic changes among a significant proportion of grafts are associated with progression of chronic changes already over the first year following transplantation. Hence they represent independent risk factors for the development of irreversible graft damage. Protocol biopsy seems to be an important method to monitor immunosuppressive therapy. (en)
Title	Protocol biopsy of a transplanted kidney as a tool for monitoring adequacy of immunosupressive therapy: 10 years of experience from a single transplant center Protocol biopsy of a transplanted kidney as a tool for monitoring adequacy of immunosupressive therapy: 10 years of experience from a single transplant center (en)
skos:prefLabel	Protocol biopsy of a transplanted kidney as a tool for monitoring adequacy of immunosupressive therapy: 10 years of experience from a single transplant center Protocol biopsy of a transplanted kidney as a tool for monitoring adequacy of immunosupressive therapy: 10 years of experience from a single transplant center (en)
skos:notation	RIV/61989592:15110/11:33116438!RIV12-MSM-15110___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Ciferská, Hana Horák, Pavel Zadražil, Josef Tichý, Tomáš Krejčí, Karel BACHLEDA, Petr Štrebl, Pavel Hrubý, Miroslav Žamboch, Kamil Horčička, Vladko
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	224854
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/11:33116438
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	subclinical rejection; subclinical nephrotoxicity; renal graft damage; protocol biopsy; kidney transplantation; calcineurin inhibitors (en)
http://linked.open.../riv/klicoveSlovo	kidney transplantation calcineurin inhibitors protocol biopsy renal graft damage subclinical nephrotoxicity subclinical rejection
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9E073168DF04]
http://linked.open...i/riv/nazevZdroje	Transplantation Proceedings
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Ciferská, Hana Hrubý, Miroslav Horák, Pavel Tichý, Tomáš Zadražil, Josef Krejčí, Karel Al-Gabri, Sadek Bachleda, Petr Horčička, Vladko Štrebl, Pavel Žamboch, Kamil
issn	0041-1345
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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