About: A Randomized Controlled Trial of Lycopene Treatment on Soluble Receptor for Advanced Glycation End Products in Seminal and Blood Plasma of Normospermic Men

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About: A Randomized Controlled Trial of Lycopene Treatment on Soluble Receptor for Advanced Glycation End Products in Seminal and Blood Plasma of Normospermic Men Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Study included 15 fertile volunteers and 13 normospermic male partners from infertile relationships. The treatment was 12-week administration of 20 mg of lycopene or placebo followed by crossover and treatment for a further 12 weeks. The ELISA kit Quantikine_ was used to determine sRAGE levels. Lycopene administration decreased sRAGE levels in seminal plasma in fertile volunteers (controls) as well as in male partners in the infertile relationships group (P = 0.008 and P = 0.012, respectively). No significant effect of lycopene on sRAGE in blood plasma was found in either group, but seminal plasma sRAGE was significantly suppressed.Lycopene decreased sRAGE in seminal, but not in blood plasma. This may be because of selective local uptake of lycopene in the male reproductive tract, namely in prostate. Decreased sRAGE may be caused by lycopene suppression of oxidative stressors and explain in part the putative improvement in fertility reported after lycopene treatment. Study included 15 fertile volunteers and 13 normospermic male partners from infertile relationships. The treatment was 12-week administration of 20 mg of lycopene or placebo followed by crossover and treatment for a further 12 weeks. The ELISA kit Quantikine_ was used to determine sRAGE levels. Lycopene administration decreased sRAGE levels in seminal plasma in fertile volunteers (controls) as well as in male partners in the infertile relationships group (P = 0.008 and P = 0.012, respectively). No significant effect of lycopene on sRAGE in blood plasma was found in either group, but seminal plasma sRAGE was significantly suppressed.Lycopene decreased sRAGE in seminal, but not in blood plasma. This may be because of selective local uptake of lycopene in the male reproductive tract, namely in prostate. Decreased sRAGE may be caused by lycopene suppression of oxidative stressors and explain in part the putative improvement in fertility reported after lycopene treatment. (en)
Title	A Randomized Controlled Trial of Lycopene Treatment on Soluble Receptor for Advanced Glycation End Products in Seminal and Blood Plasma of Normospermic Men A Randomized Controlled Trial of Lycopene Treatment on Soluble Receptor for Advanced Glycation End Products in Seminal and Blood Plasma of Normospermic Men (en)
skos:prefLabel	A Randomized Controlled Trial of Lycopene Treatment on Soluble Receptor for Advanced Glycation End Products in Seminal and Blood Plasma of Normospermic Men A Randomized Controlled Trial of Lycopene Treatment on Soluble Receptor for Advanced Glycation End Products in Seminal and Blood Plasma of Normospermic Men (en)
skos:notation	RIV/61989592:15110/11:33115907!RIV14-MZ0-15110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(1A8621), P(NT11083)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Molíková, Radka Novotný, Jiří Oborná, Ivana Fingerová, Helena Březinová, Jana Svobodová, Magda
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	184098
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/11:33115907
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	sRAGE; seminal plasma; normospermia; lycopene; Blood plasma (en)
http://linked.open.../riv/klicoveSlovo	Blood plasma lycopene normospermia sRAGE seminal plasma
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DF64CC26BC99]
http://linked.open...i/riv/nazevZdroje	American Journal of Reproductive Immunology
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Oxidative stress in pathophysiology of male infertility. Selection of functional spermatozoa using chosen biomarkers in diagnosis of male infertility
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	66
http://linked.open...iv/tvurceVysledku	Bryndová, Hana Březinová, Jana Fingerová, Helena Horká, Petra Malíčková, Karin Molíková, Radka Novotný, Jiří Oborná, Ivana Svobodová, Magda
issn	1046-7408
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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