About: Aberrant Glycosylation of IgA 1 and AntiGlycan Antibodies in IgA Nephropathy: Role of Mucosal Immune System

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About: Aberrant Glycosylation of IgA 1 and AntiGlycan Antibodies in IgA Nephropathy: Role of Mucosal Immune System Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	IgA nephropathy (IgAN), the most common glomerulonephritis, is characterized by mesangial IgA1-containing immunodeposits, proliferation of mesangial cells, and matrix expansion. Clinical onset is frequently heralded by synpharyngitic hematuria, macroscopic hematuria during an upper-respiratory tract infection. Clinical and laboratory data support a postulated extrarenal origin of the glomerular IgA1, likely derived from circulating immune complexes containing polymeric IgA1, deficient in galactose in the hinge-region O-glycans, bound by antiglycan antibodies. This aberrant IgA1 is produced by IgA1-secreting cells with abnormal activities of specific glycosyltransferases. IgA nephropathy (IgAN), the most common glomerulonephritis, is characterized by mesangial IgA1-containing immunodeposits, proliferation of mesangial cells, and matrix expansion. Clinical onset is frequently heralded by synpharyngitic hematuria, macroscopic hematuria during an upper-respiratory tract infection. Clinical and laboratory data support a postulated extrarenal origin of the glomerular IgA1, likely derived from circulating immune complexes containing polymeric IgA1, deficient in galactose in the hinge-region O-glycans, bound by antiglycan antibodies. This aberrant IgA1 is produced by IgA1-secreting cells with abnormal activities of specific glycosyltransferases. (en)
Title	Aberrant Glycosylation of IgA 1 and AntiGlycan Antibodies in IgA Nephropathy: Role of Mucosal Immune System Aberrant Glycosylation of IgA 1 and AntiGlycan Antibodies in IgA Nephropathy: Role of Mucosal Immune System (en)
skos:prefLabel	Aberrant Glycosylation of IgA 1 and AntiGlycan Antibodies in IgA Nephropathy: Role of Mucosal Immune System Aberrant Glycosylation of IgA 1 and AntiGlycan Antibodies in IgA Nephropathy: Role of Mucosal Immune System (en)
skos:notation	RIV/61989592:15110/11:10224921!RIV12-MZ0-15110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP304/10/1951), P(NT11081)
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	RAŠKA, Milan
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	184292
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/11:10224921
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	IgA nephropathy (en)
http://linked.open.../riv/klicoveSlovo	IgA nephropathy
http://linked.open...ontrolniKodProRIV	[86CF584F4C17]
http://linked.open...v/mistoKonaniAkce	Asahikawa, Japan
http://linked.open...i/riv/mistoVydani	Basel
http://linked.open...i/riv/nazevZdroje	Advances in Oto-Rhino-Laryngology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Nanoliposomes for development of recombinant vaccines and targetted immunotherapeutics Molecular approaches for elimination or inactivation of pathogenic circulating immune complexes in IgA nephropathy and Henoch-Schoenlein purpura.
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Gharavi, Alli Julian, Bruce Moldoveanu, Zina Městacký, Jiří Novák, Jan RAŠKA, Milan Suzuki, Hitoshi Suzuki, Yusuke Tomino, Yusuhiko Wyatt, Robert
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2010-07-07 (xsd:date)
issn	0065-3071
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	S. Karger AG
https://schema.org/isbn	978-3-8055-9722-7
http://localhost/t...ganizacniJednotka	15110

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