About: Chronic Myeloid Leukemia Patients in Prolonged Remission following Interferon-alfa Monotherapy Have Distinct Cytokine and Oligoclonal Lymphocyte Profile

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About: Chronic Myeloid Leukemia Patients in Prolonged Remission following Interferon-alfa Monotherapy Have Distinct Cytokine and Oligoclonal Lymphocyte Profile Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Before the era of tyrosine kinase inhibitors (TKIs), interferon-alpha (IFN-a) was the treatment of choice in chronic myeloid leukemia (CML). Curiously, some IFN-a treated patients were able to discontinue therapy without disease progression. The aim of this project was to study the immunomodulatory effects of IFN-a in CML patients in prolonged remission and isolate biological markers predicting response. Due to rarity of patients on IFN-a monotherapy, a relatively small cohort of patients still on treatment (IFN-ON, n = 10, median therapy duration 11.8 years) or had discontinued IFN-a therapy but remained in remission for .2 years (IFN-OFF, n = 9) were studied. Before the era of tyrosine kinase inhibitors (TKIs), interferon-alpha (IFN-a) was the treatment of choice in chronic myeloid leukemia (CML). Curiously, some IFN-a treated patients were able to discontinue therapy without disease progression. The aim of this project was to study the immunomodulatory effects of IFN-a in CML patients in prolonged remission and isolate biological markers predicting response. Due to rarity of patients on IFN-a monotherapy, a relatively small cohort of patients still on treatment (IFN-ON, n = 10, median therapy duration 11.8 years) or had discontinued IFN-a therapy but remained in remission for .2 years (IFN-OFF, n = 9) were studied. (en)
Title	Chronic Myeloid Leukemia Patients in Prolonged Remission following Interferon-alfa Monotherapy Have Distinct Cytokine and Oligoclonal Lymphocyte Profile Chronic Myeloid Leukemia Patients in Prolonged Remission following Interferon-alfa Monotherapy Have Distinct Cytokine and Oligoclonal Lymphocyte Profile (en)
skos:prefLabel	Chronic Myeloid Leukemia Patients in Prolonged Remission following Interferon-alfa Monotherapy Have Distinct Cytokine and Oligoclonal Lymphocyte Profile Chronic Myeloid Leukemia Patients in Prolonged Remission following Interferon-alfa Monotherapy Have Distinct Cytokine and Oligoclonal Lymphocyte Profile (en)
skos:notation	RIV/61989592:15110/11:10223892!RIV12-MSM-15110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6198959205), Z(MSM6198959223)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Faber, Edgar INDRÁK, Karel Rohoň, Peter
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	190344
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/11:10223892
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	remission; chronic myeloid leukemia (en)
http://linked.open.../riv/klicoveSlovo	chronic myeloid leukemia remission
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2EEE6746E6EC]
http://linked.open...i/riv/nazevZdroje	PLoS One
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Arstila, Petteri Faber, Edgar Flochová, Emília Indrák, Karel Juvonen, Vesa Kairisto, Veli Kreutzman, Anna Mustjoki, Satu Porkka, Kimmo Rohoň, Peter Sinisalo, Marjatta Vakkila, Jukka Voglová, Jaroslava
http://linked.open...n/vavai/riv/zamer	Studies of genes and molecular mechanisms involved in regulation of hematopoiesis, their clinical impact and targeted treatment Nové možnosti diagnostiky a imunomodulace u infekčních onemocnění a imunopatologických stavů
issn	1932-6203
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pone.0023022
http://localhost/t...ganizacniJednotka	15110

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