About: Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in Armenian population

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aberrant neurodevelopment contributes to the etiology of schizophrenia. This study aimed to investigate the potential association of netrin G1 (NTNG1) rs628117 and brain-derived neurotrophic factor (BDNF)Val66Met(rs6265) genetic polymorphisms with susceptibility to schizophrenia. One hundred three Armenian patients with schizophrenia and 105 healthy control subjects were genotyped by polymerase chain reaction with sequence-specific primers. Whereas the NTNG1 rs628117 genotypes were equally distributed in the groups, the carriers of the less common BDNF 66Met allele were overrepresented among patients with schizophrenia when compared with healthy controls (55% vs 35%, odds ratio=2.28, 95% confidence interval 1.14-1.98, p(corrected)=0.006). Furthermore, the 66Met/Met genotype correlated with earlier disease onset (p=0.024). In conclusion, our single-cohort study nominates the BDNF 66Met allele as a risk factor for schizophrenia in an Armenian population. This must be confirmed in other Armenian cohorts. Aberrant neurodevelopment contributes to the etiology of schizophrenia. This study aimed to investigate the potential association of netrin G1 (NTNG1) rs628117 and brain-derived neurotrophic factor (BDNF)Val66Met(rs6265) genetic polymorphisms with susceptibility to schizophrenia. One hundred three Armenian patients with schizophrenia and 105 healthy control subjects were genotyped by polymerase chain reaction with sequence-specific primers. Whereas the NTNG1 rs628117 genotypes were equally distributed in the groups, the carriers of the less common BDNF 66Met allele were overrepresented among patients with schizophrenia when compared with healthy controls (55% vs 35%, odds ratio=2.28, 95% confidence interval 1.14-1.98, p(corrected)=0.006). Furthermore, the 66Met/Met genotype correlated with earlier disease onset (p=0.024). In conclusion, our single-cohort study nominates the BDNF 66Met allele as a risk factor for schizophrenia in an Armenian population. This must be confirmed in other Armenian cohorts. (en)
Title	Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in Armenian population Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in Armenian population (en)
skos:prefLabel	Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in Armenian population Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in Armenian population (en)
skos:notation	RIV/61989592:15110/11:10223080!RIV12-MSM-15110___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM6198959205)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Petřek, Martin Mrázek, František
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	200537
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/11:10223080
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	single nucleotide polymorphisms; netrin G1; brain derived neurotrophic factor; neurodevelopment; schizophrenia (en)
http://linked.open.../riv/klicoveSlovo	brain derived neurotrophic factor netrin G1 neurodevelopment single nucleotide polymorphisms schizophrenia
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E8DBB1788FC2]
http://linked.open...i/riv/nazevZdroje	Human Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	72
http://linked.open...iv/tvurceVysledku	Arakelyan, Arsen Boyajyan, Anna Gevorgyan, Anaida Mrázek, František Petřek, Martin Zakharyan, Roksana
http://linked.open...n/vavai/riv/zamer	Studies of genes and molecular mechanisms involved in regulation of hematopoiesis, their clinical impact and targeted treatment
issn	0198-8859
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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