About: Subclinical toxicity of calcineurin inhibitors in repeated protocol biopsies: an independent risk factor for chronic kidney allograft damage

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About: Subclinical toxicity of calcineurin inhibitors in repeated protocol biopsies: an independent risk factor for chronic kidney allograft damage Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The purpose of the prospective study was to determine the prevalence of subclinical toxicity of calcineurin inhibitors (CI) in repeated protocol renal allograft biopsies and to assess its impact on the development of chronic graft changes. A total of 424 biopsies were conducted in a cohort of 158 patients; of these biopsies, 158 were in the third week, 142 were in the third month and 124 were in the first year after transplantation. Histological signs of toxicity occurred in the third week in 33 (20,1%) patients, with persistence after CI dose reduction in the third month in 27 (19,0%) and in the rist year in 23 (18,5%) patients. Of the toxic changes, 52% were clinically silent. The purpose of the prospective study was to determine the prevalence of subclinical toxicity of calcineurin inhibitors (CI) in repeated protocol renal allograft biopsies and to assess its impact on the development of chronic graft changes. A total of 424 biopsies were conducted in a cohort of 158 patients; of these biopsies, 158 were in the third week, 142 were in the third month and 124 were in the first year after transplantation. Histological signs of toxicity occurred in the third week in 33 (20,1%) patients, with persistence after CI dose reduction in the third month in 27 (19,0%) and in the rist year in 23 (18,5%) patients. Of the toxic changes, 52% were clinically silent. (en)
Title	Subclinical toxicity of calcineurin inhibitors in repeated protocol biopsies: an independent risk factor for chronic kidney allograft damage Subclinical toxicity of calcineurin inhibitors in repeated protocol biopsies: an independent risk factor for chronic kidney allograft damage (en)
skos:prefLabel	Subclinical toxicity of calcineurin inhibitors in repeated protocol biopsies: an independent risk factor for chronic kidney allograft damage Subclinical toxicity of calcineurin inhibitors in repeated protocol biopsies: an independent risk factor for chronic kidney allograft damage (en)
skos:notation	RIV/61989592:15110/10:10219236!RIV11-MSM-15110___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Ciferská, Hana Horák, Pavel Zadražil, Josef Tichý, Tomáš Krejčí, Karel BACHLEDA, Petr Štrebl, Pavel Hrubý, Miroslav Horčička, Vladko
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	290919
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/10:10219236
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	subclinical nephrotoxicity; renal allograft damage; protocol biopsy; kidney transplantation; calcineurin inhibitors; Bangg chronicity score (en)
http://linked.open.../riv/klicoveSlovo	kidney transplantation calcineurin inhibitors protocol biopsy subclinical nephrotoxicity Bangg chronicity score renal allograft damage
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[BDB8E89134D5]
http://linked.open...i/riv/nazevZdroje	Transplant International
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Ciferská, Hana Hrubý, Miroslav Horák, Pavel Tichý, Tomáš Zadražil, Josef Krejčí, Karel Bachleda, Petr Horčička, Vladko Štrebl, Pavel Al-Jabry, Sadek
issn	0934-0874
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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