About: HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes     Goto   Sponge   NotDistinct   Permalink

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  • Regulatory ubiquitylation is emerging as an important mechanism to protect genome integrity in cells exposed to DNA damage1-9. However, the spectrum of known ubiquitin regulators of the DNA damage response (DDR) is limited and their functional interplay is poorly understood. Here, we identify ERC2 as a factor that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes.
  • Regulatory ubiquitylation is emerging as an important mechanism to protect genome integrity in cells exposed to DNA damage1-9. However, the spectrum of known ubiquitin regulators of the DNA damage response (DDR) is limited and their functional interplay is poorly understood. Here, we identify ERC2 as a factor that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. (en)
Title
  • HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
  • HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes (en)
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  • HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
  • HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes (en)
skos:notation
  • RIV/61989592:15110/10:10215634!RIV13-MSM-15110___
http://linked.open...avai/riv/aktivita
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  • Z(MSM6198959216)
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  • 1
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  • 261410
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  • RIV/61989592:15110/10:10215634
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  • DNA repair; ubiquitin-dependent; HERC2 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
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  • [F32BBB9A595F]
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  • Nature Cell Biology (print)
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  • 12
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  • Bártek, Jiří
  • Lukáš, Jiří
  • Bekker-Jensen, Simon
  • Fugger, Kasper
  • Mailand, Niels
  • Danielsen, Jannie
  • Gromova, Irina
  • Nerstedt, Anika
http://linked.open...ain/vavai/riv/wos
  • 000272973800016
http://linked.open...n/vavai/riv/zamer
issn
  • 1465-7392
number of pages
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  • 10.1038/ncb2008
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  • 15110
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