About: Calcineurin inhibitor-induced renal allograft nephrotoxicity

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The introduction of the calcineurin inhibitors (CI) cyclosporine and tacrolimus into immunosuppressive protocols initiated a new era in organ transplantation with excellent short-term graft survival. Nevertheless, the chronic nephrotoxicity of these drugs represents a significant adverse factor limiting their long-term use. Patients treated with a CI can be at risk for developing renal failure and this problem is especially pronounced in patients after renal transplantation. Over to their unique effects, CI remain the cornerstone of most immunosuppressive protocols for renat transplantation. Together with optimization of local kidney exposure to CI and their metabolities, efforts to reduce systemic levels as much as possible are the most important preventive measure for reducing toxic renal graft damage. The introduction of the calcineurin inhibitors (CI) cyclosporine and tacrolimus into immunosuppressive protocols initiated a new era in organ transplantation with excellent short-term graft survival. Nevertheless, the chronic nephrotoxicity of these drugs represents a significant adverse factor limiting their long-term use. Patients treated with a CI can be at risk for developing renal failure and this problem is especially pronounced in patients after renal transplantation. Over to their unique effects, CI remain the cornerstone of most immunosuppressive protocols for renat transplantation. Together with optimization of local kidney exposure to CI and their metabolities, efforts to reduce systemic levels as much as possible are the most important preventive measure for reducing toxic renal graft damage. (en)
Title	Calcineurin inhibitor-induced renal allograft nephrotoxicity Calcineurin inhibitor-induced renal allograft nephrotoxicity (en)
skos:prefLabel	Calcineurin inhibitor-induced renal allograft nephrotoxicity Calcineurin inhibitor-induced renal allograft nephrotoxicity (en)
skos:notation	RIV/61989592:15110/10:10213431!RIV11-MSM-15110___
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Zadražil, Josef Tichý, Tomáš Krejčí, Karel BACHLEDA, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	249472
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/10:10213431
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	prevention; risk factors; nephrotoxicity; renal allograft; cyclosporine and tacrolimus; calcineurin inhibitors (en)
http://linked.open.../riv/klicoveSlovo	risk factors renal allograft prevention cyclosporine and tacrolimus calcineurin inhibitors nephrotoxicity
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[8335B818B84F]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	154
http://linked.open...iv/tvurceVysledku	Tichý, Tomáš Zadražil, Josef Krejčí, Karel Bachleda, Petr
issn	1213-8118
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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