About: Repeated chemosensitivity testing in patiens with epithelial ovarian carcinoma.

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Epithelial ovarian carcinoma (EOC) is a highly chemosensitive tumor, but most patients with advanced EOC initially responding to first-line chemotherapy with eventually relapse. Chemosensitivity testing may offer an opportunity for the optimal selection of chemotherapeutic agents for individual patients. In the present retrospective analysis we have examined the changes in chemosensitivity profiles during the course of the disease. Chemosensitivity was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5.diphenyl tetrazolium bromide (MTT) test. Two or more samples at least 14 days apart were obtained from 34 patients with ovarian cancer. Chemoresistance increased significantly at the second measurement only for paclitaxel and carbplatin, the most frequently used cytotoxic drugs. No significant difference compared to baseline was observed at subsequent measurements for any other cytotoxic agent studied, although a non-significant trend for increased chemoresistance was observed. Epithelial ovarian carcinoma (EOC) is a highly chemosensitive tumor, but most patients with advanced EOC initially responding to first-line chemotherapy with eventually relapse. Chemosensitivity testing may offer an opportunity for the optimal selection of chemotherapeutic agents for individual patients. In the present retrospective analysis we have examined the changes in chemosensitivity profiles during the course of the disease. Chemosensitivity was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5.diphenyl tetrazolium bromide (MTT) test. Two or more samples at least 14 days apart were obtained from 34 patients with ovarian cancer. Chemoresistance increased significantly at the second measurement only for paclitaxel and carbplatin, the most frequently used cytotoxic drugs. No significant difference compared to baseline was observed at subsequent measurements for any other cytotoxic agent studied, although a non-significant trend for increased chemoresistance was observed. (en)
Title	Repeated chemosensitivity testing in patiens with epithelial ovarian carcinoma. Repeated chemosensitivity testing in patiens with epithelial ovarian carcinoma. (en)
skos:prefLabel	Repeated chemosensitivity testing in patiens with epithelial ovarian carcinoma. Repeated chemosensitivity testing in patiens with epithelial ovarian carcinoma. (en)
skos:notation	RIV/61989592:15110/10:10213297!RIV11-MSM-15110___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(LC07017), S, Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Špenerová, Michaela Melichar, Bohuslav Hajdúch, Marián Pilka, Radovan Kudela, Milan Šrámek, Vlastislav Cwiertka, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	284833
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/10:10213297
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Platinum; Epithelial ovarian carcinoma: Paclitaxel; Chemosensitivity (en)
http://linked.open.../riv/klicoveSlovo	Chemosensitivity Epithelial ovarian carcinoma: Paclitaxel Platinum
http://linked.open...odStatuVydavatele	IT - Italská republika
http://linked.open...ontrolniKodProRIV	[E4D188454C7A]
http://linked.open...i/riv/nazevZdroje	EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Oncoproteomics Centre
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Hajdúch, Marián Melichar, Bohuslav Šrámek, Vlastislav Pilka, Radovan Kudela, Milan Cwiertka, Karel Pospíšková, Markéta Špenerová, Michaela
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0392-2936
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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