About: Polyphenolic fraction of Lonicera caerulea L. fruits reduces oxidative stress and inflammatory markers induced by lipopolysaccharide in gingival fibroblasts

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About: Polyphenolic fraction of Lonicera caerulea L. fruits reduces oxidative stress and inflammatory markers induced by lipopolysaccharide in gingival fibroblasts Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The most common oral diseases have a microbial aetiology. Pathogenic bacteria liberate a number of irritating agents including a lipopolysaccharide (LPS) that activates pro-inflammatory cytokines promoting increased activity of polymorphonucleocytes (PMN). Berries of Lonicera caerulea L. are rich in phenolic acids, flavonoids and anthocyanins that have multiple biological activities in vitro and in vivo. Studies have shown that polyphenols suppress a number of LPS-induced signals. We assessed effects of the polyphenolic fraction of L. caerulea fruits (PFLC; 77% anthocyanins) on LPS-induced oxidative damage and inflammation in human gingival fibroblasts. PFLC (10-50mug/ml) reduced reactive oxygen species production, intracellular glutathione depletion and lipid peroxidation in LPS-treated cells. PFLC treatment also inhibited LPS-induced up-regulation of interleukin-1beta, interleukin-6 and tumour necrosis factor-alpha and it suppressed expression of cyclooxygenase-2. The most common oral diseases have a microbial aetiology. Pathogenic bacteria liberate a number of irritating agents including a lipopolysaccharide (LPS) that activates pro-inflammatory cytokines promoting increased activity of polymorphonucleocytes (PMN). Berries of Lonicera caerulea L. are rich in phenolic acids, flavonoids and anthocyanins that have multiple biological activities in vitro and in vivo. Studies have shown that polyphenols suppress a number of LPS-induced signals. We assessed effects of the polyphenolic fraction of L. caerulea fruits (PFLC; 77% anthocyanins) on LPS-induced oxidative damage and inflammation in human gingival fibroblasts. PFLC (10-50mug/ml) reduced reactive oxygen species production, intracellular glutathione depletion and lipid peroxidation in LPS-treated cells. PFLC treatment also inhibited LPS-induced up-regulation of interleukin-1beta, interleukin-6 and tumour necrosis factor-alpha and it suppressed expression of cyclooxygenase-2. (en)
Title	Polyphenolic fraction of Lonicera caerulea L. fruits reduces oxidative stress and inflammatory markers induced by lipopolysaccharide in gingival fibroblasts Polyphenolic fraction of Lonicera caerulea L. fruits reduces oxidative stress and inflammatory markers induced by lipopolysaccharide in gingival fibroblasts (en)
skos:prefLabel	Polyphenolic fraction of Lonicera caerulea L. fruits reduces oxidative stress and inflammatory markers induced by lipopolysaccharide in gingival fibroblasts Polyphenolic fraction of Lonicera caerulea L. fruits reduces oxidative stress and inflammatory markers induced by lipopolysaccharide in gingival fibroblasts (en)
skos:notation	RIV/61989592:15110/10:10213260!RIV11-MSM-15110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(FT-TA3/024), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Šimánek, Vilím Chytilová, Karin Rajnochová Svobodová, Alena Ulrichová, Jitka Galandáková, Adéla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	279807
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/10:10213260
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cyclooxygenase-2; Cytokines; Reactive oxygen species; Anti-inflammatory activity; Antioxidant; Lonicera caerulea L. (en)
http://linked.open.../riv/klicoveSlovo	Reactive oxygen species Antioxidant Anti-inflammatory activity Cyclooxygenase-2 Lonicera caerulea L. Cytokines
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B8869FAF6B0E]
http://linked.open...i/riv/nazevZdroje	Food and Chemical Toxicology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Plant chemoprotectants - New food supplements for health and prevention of chronic diseases.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	48
http://linked.open...iv/tvurceVysledku	Rajnochová Svobodová, Alena Ulrichová, Jitka Šimánek, Vilím Chytilová, Karin Zdařilová, Adéla
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0278-6915
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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