About: Ion-trap mass spectrometry for determination of 3,5,3'-triiodo-l-thyronine and 3,5,3',5'-tetraiodo-l-thyronine in neonatal rat cardiomyocytes

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About: Ion-trap mass spectrometry for determination of 3,5,3'-triiodo-l-thyronine and 3,5,3',5'-tetraiodo-l-thyronine in neonatal rat cardiomyocytes Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Our short report describes a method employing electrospray ion-trap mass spectrometry (MS) connected to a reversed phase (C(8)) HPLC system for monitoring of 3,5,3'-triiodo-l-thyronine (T3) and its precursor 3,5,3',5'-tetraiodo-l-thyronine (T4) in neonatal rat cardiomyocytes. The experimental protocol allows simultaneous analysis of the free thyroid hormones in nanomolar concentration range and enables observation of their distribution in cultivation medium over time. The method is a useful tool for MS(2) identification of T3/T4 and analysis of their uptake into mammalian cells. Our short report describes a method employing electrospray ion-trap mass spectrometry (MS) connected to a reversed phase (C(8)) HPLC system for monitoring of 3,5,3'-triiodo-l-thyronine (T3) and its precursor 3,5,3',5'-tetraiodo-l-thyronine (T4) in neonatal rat cardiomyocytes. The experimental protocol allows simultaneous analysis of the free thyroid hormones in nanomolar concentration range and enables observation of their distribution in cultivation medium over time. The method is a useful tool for MS(2) identification of T3/T4 and analysis of their uptake into mammalian cells. (en)
Title	Ion-trap mass spectrometry for determination of 3,5,3'-triiodo-l-thyronine and 3,5,3',5'-tetraiodo-l-thyronine in neonatal rat cardiomyocytes Ion-trap mass spectrometry for determination of 3,5,3'-triiodo-l-thyronine and 3,5,3',5'-tetraiodo-l-thyronine in neonatal rat cardiomyocytes (en)
skos:prefLabel	Ion-trap mass spectrometry for determination of 3,5,3'-triiodo-l-thyronine and 3,5,3',5'-tetraiodo-l-thyronine in neonatal rat cardiomyocytes Ion-trap mass spectrometry for determination of 3,5,3'-triiodo-l-thyronine and 3,5,3',5'-tetraiodo-l-thyronine in neonatal rat cardiomyocytes (en)
skos:notation	RIV/61989592:15110/10:10213250!RIV11-GA0-15110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA303/08/0658), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vacek, Jan GABRIELOVÁ, Eva Ulrichová, Jitka Modrianský, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	264910
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/10:10213250
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cardiomyocytes; Liquid chromatography; Mass spectrometry; Analytical tool; Thyroxine; Iodinated thyronines (en)
http://linked.open.../riv/klicoveSlovo	Liquid chromatography Mass spectrometry Analytical tool Iodinated thyronines Cardiomyocytes Thyroxine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3256DF096574]
http://linked.open...i/riv/nazevZdroje	Journal of Pharmaceutical and Biomedical Analysis
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Modulation of uncoupling protein UcP2 and mitochondrial bioenergetics in cardiomyocytes by natural substances
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	53
http://linked.open...iv/tvurceVysledku	Kosina, Pavel Ulrichová, Jitka Vacek, Jan Modrianský, Martin GABRIELOVÁ, Eva
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0731-7085
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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