About: The radiosensitising effect of olomoucine derived synthetic cyclin-dependent kinase inhibitors     Goto   Sponge   NotDistinct   Permalink

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  • Bohemine and roscovitine are the most important representatives of the group of compounds structurally derived from olomoucine. Biologically they function as inhibitors of cyclin-dependent kinases (CDKs), the key regulators of cell cycle, which is often disrupted in cancer cells resulting in uncontrollable proliferation. Bohemine and roscovitine have demonstrated their cytostatic and cytotoxic in vitro and also in vivo effects. Currently the phase II clinical trials for roscovitine are underway. The aim of the study was to evaluate the potential in vitro radiosensitising effect of bohemine (BOH) and roscovitine (ROS). Clonogenic survival assay and human lung adenocarcinoma cell line A549 were used. Tested schedules were: A-pretreatment, B-concomitant application and C-posttreatment. Concentrations corresponded to IC10, IC25 and IC50 for BOH/ROS (0.1-30 mýM). The radiation doses were 1, 2 and 3 Gy.
  • Bohemine and roscovitine are the most important representatives of the group of compounds structurally derived from olomoucine. Biologically they function as inhibitors of cyclin-dependent kinases (CDKs), the key regulators of cell cycle, which is often disrupted in cancer cells resulting in uncontrollable proliferation. Bohemine and roscovitine have demonstrated their cytostatic and cytotoxic in vitro and also in vivo effects. Currently the phase II clinical trials for roscovitine are underway. The aim of the study was to evaluate the potential in vitro radiosensitising effect of bohemine (BOH) and roscovitine (ROS). Clonogenic survival assay and human lung adenocarcinoma cell line A549 were used. Tested schedules were: A-pretreatment, B-concomitant application and C-posttreatment. Concentrations corresponded to IC10, IC25 and IC50 for BOH/ROS (0.1-30 mýM). The radiation doses were 1, 2 and 3 Gy. (en)
Title
  • The radiosensitising effect of olomoucine derived synthetic cyclin-dependent kinase inhibitors
  • The radiosensitising effect of olomoucine derived synthetic cyclin-dependent kinase inhibitors (en)
skos:prefLabel
  • The radiosensitising effect of olomoucine derived synthetic cyclin-dependent kinase inhibitors
  • The radiosensitising effect of olomoucine derived synthetic cyclin-dependent kinase inhibitors (en)
skos:notation
  • RIV/61989592:15110/10:10213228!RIV11-MSM-15110___
http://linked.open...avai/riv/aktivita
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  • P(LC07017), S, Z(MSM6198959216)
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  • 2
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  • 283780
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  • RIV/61989592:15110/10:10213228
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http://linked.open.../riv/klicovaSlova
  • DNA repair; CDK inhibitor; radiosensitisation; roscovitine; Bohemine (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SK - Slovenská republika
http://linked.open...ontrolniKodProRIV
  • [B6CF479FD17E]
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  • Neoplasma
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http://linked.open...v/svazekPeriodika
  • 57
http://linked.open...iv/tvurceVysledku
  • Džubák, Petr
  • Hajdúch, Marián
  • Kořínková, Gabriela
  • Cwiertka, Karel
  • Paprskářová, Martina
http://linked.open...n/vavai/riv/zamer
issn
  • 0028-2685
number of pages
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  • 15110
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