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  • To investigate the temporal regulation of the DNA damage response, we applied quantitative mass spectrometry-based proteomics to measure site-specific phosphorylation changes of nuclear proteins after ionizing radiation. We profiled 5204 phosphorylation sites at five time points following DNA damage of which 594 sites on 209 proteins were observed to be regulated more than 2-fold. Of the 594 sites, 372 are novel phosphorylation sites primarily of nuclear origin. The 594 sites could be classified to distinct temporal profiles. Sites regulated shortly after radiation were enriched in the ataxia telangiectasia mutated (ATM) kinase SQ consensus sequence motif and a novel SXXQ motif. Importantly, in addition to induced phosphorylation, we identified a considerable group of sites that undergo DNA damage-induced dephosphorylation.
  • To investigate the temporal regulation of the DNA damage response, we applied quantitative mass spectrometry-based proteomics to measure site-specific phosphorylation changes of nuclear proteins after ionizing radiation. We profiled 5204 phosphorylation sites at five time points following DNA damage of which 594 sites on 209 proteins were observed to be regulated more than 2-fold. Of the 594 sites, 372 are novel phosphorylation sites primarily of nuclear origin. The 594 sites could be classified to distinct temporal profiles. Sites regulated shortly after radiation were enriched in the ataxia telangiectasia mutated (ATM) kinase SQ consensus sequence motif and a novel SXXQ motif. Importantly, in addition to induced phosphorylation, we identified a considerable group of sites that undergo DNA damage-induced dephosphorylation. (en)
Title
  • Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response
  • Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response (en)
skos:prefLabel
  • Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response
  • Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response (en)
skos:notation
  • RIV/61989592:15110/10:10213211!RIV13-MSM-15110___
http://linked.open...avai/riv/aktivita
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  • Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
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  • 287611
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  • RIV/61989592:15110/10:10213211
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  • complex; biology; checkpoint; methylation; networks; set domain; gene ontology; mass-spectrometer; peptide identification; double-strand breaks (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [398C40B3CC7C]
http://linked.open...i/riv/nazevZdroje
  • Molecular and Cellular Proteomics
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  • 9
http://linked.open...iv/tvurceVysledku
  • Bártek, Jiří
  • Lukáš, Jiří
  • Andersen, Jens
  • Larsen, Dorthe
  • Bennetzen, Martin
  • Bunkenborg, Jakob
http://linked.open...ain/vavai/riv/wos
  • 000279396900021
http://linked.open...n/vavai/riv/zamer
issn
  • 1535-9476
number of pages
http://bibframe.org/vocab/doi
  • 10.1074/mcp.M900616-MCP200
http://localhost/t...ganizacniJednotka
  • 15110
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