About: The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

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About: The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In response to ionizing radiation (IR), cells delay cell cycle progression and activate DNA repair. Both processes are vital for genome integrity, but the mechanisms involved in their coordination are not fully understood. In a mass spectrometry screen, we identified the adenosine triphosphate-dependent chromatin-remodeling protein CHD4 (chromodomain helicase DNA-binding protein 4) as a factor that becomes transiently immobilized on chromatin after IR. Knockdown of CHD4 triggers enhanced Cdc25A degradation and p21(Cip1) accumulation, which lead to more pronounced cyclin-dependent kinase inhibition and extended cell cycle delay. At DNA double-strand breaks, depletion of CHD4 disrupts the chromatin response at the level of the RNF168 ubiquitin ligase, which in turn impairs local ubiquitylation and BRCA1 assembly. These cell cycle and chromatin defects are accompanied by elevated spontaneous and IR-induced DNA breakage, reduced efficiency of DNA repair, and decreased clonogenic survival. In response to ionizing radiation (IR), cells delay cell cycle progression and activate DNA repair. Both processes are vital for genome integrity, but the mechanisms involved in their coordination are not fully understood. In a mass spectrometry screen, we identified the adenosine triphosphate-dependent chromatin-remodeling protein CHD4 (chromodomain helicase DNA-binding protein 4) as a factor that becomes transiently immobilized on chromatin after IR. Knockdown of CHD4 triggers enhanced Cdc25A degradation and p21(Cip1) accumulation, which lead to more pronounced cyclin-dependent kinase inhibition and extended cell cycle delay. At DNA double-strand breaks, depletion of CHD4 disrupts the chromatin response at the level of the RNF168 ubiquitin ligase, which in turn impairs local ubiquitylation and BRCA1 assembly. These cell cycle and chromatin defects are accompanied by elevated spontaneous and IR-induced DNA breakage, reduced efficiency of DNA repair, and decreased clonogenic survival. (en)
Title	The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage (en)
skos:prefLabel	The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage (en)
skos:notation	RIV/61989592:15110/10:10213205!RIV13-MSM-15110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Bártek, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	250702
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/10:10213205
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DESTRUCTION; CHROMOSOMES; MDC1; CANCER; CHECKPOINT; S-PHASE; NURD COMPLEX; IONIZING-RADIATION; HISTONE DEACETYLASE; DOUBLE-STRAND BREAKS (en)
http://linked.open.../riv/klicoveSlovo	CANCER DESTRUCTION CHECKPOINT DOUBLE-STRAND BREAKS CHROMOSOMES HISTONE DEACETYLASE IONIZING-RADIATION MDC1 NURD COMPLEX S-PHASE
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9FAFA1F3B31A]
http://linked.open...i/riv/nazevZdroje	Journal of Cell Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	190
http://linked.open...iv/tvurceVysledku	Bártek, Jiří Lukáš, Jiří Lukas, Claudia Andersen, Jens Danielsen, Jannie Dinant, Christoffel Gudjonsson, Thorkell Hari, Flurina Larsen, Dorthe Menard, Patrice Payne, Mark Poinsignon, Catherine Sand, Jette Stucki, Manuel
http://linked.open...ain/vavai/riv/wos	000281781300005
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0021-9525
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1083/jcb.200912135
http://localhost/t...ganizacniJednotka	15110

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