About: The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage     Goto   Sponge   NotDistinct   Permalink

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  • In response to ionizing radiation (IR), cells delay cell cycle progression and activate DNA repair. Both processes are vital for genome integrity, but the mechanisms involved in their coordination are not fully understood. In a mass spectrometry screen, we identified the adenosine triphosphate-dependent chromatin-remodeling protein CHD4 (chromodomain helicase DNA-binding protein 4) as a factor that becomes transiently immobilized on chromatin after IR. Knockdown of CHD4 triggers enhanced Cdc25A degradation and p21(Cip1) accumulation, which lead to more pronounced cyclin-dependent kinase inhibition and extended cell cycle delay. At DNA double-strand breaks, depletion of CHD4 disrupts the chromatin response at the level of the RNF168 ubiquitin ligase, which in turn impairs local ubiquitylation and BRCA1 assembly. These cell cycle and chromatin defects are accompanied by elevated spontaneous and IR-induced DNA breakage, reduced efficiency of DNA repair, and decreased clonogenic survival.
  • In response to ionizing radiation (IR), cells delay cell cycle progression and activate DNA repair. Both processes are vital for genome integrity, but the mechanisms involved in their coordination are not fully understood. In a mass spectrometry screen, we identified the adenosine triphosphate-dependent chromatin-remodeling protein CHD4 (chromodomain helicase DNA-binding protein 4) as a factor that becomes transiently immobilized on chromatin after IR. Knockdown of CHD4 triggers enhanced Cdc25A degradation and p21(Cip1) accumulation, which lead to more pronounced cyclin-dependent kinase inhibition and extended cell cycle delay. At DNA double-strand breaks, depletion of CHD4 disrupts the chromatin response at the level of the RNF168 ubiquitin ligase, which in turn impairs local ubiquitylation and BRCA1 assembly. These cell cycle and chromatin defects are accompanied by elevated spontaneous and IR-induced DNA breakage, reduced efficiency of DNA repair, and decreased clonogenic survival. (en)
Title
  • The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage
  • The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage (en)
skos:prefLabel
  • The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage
  • The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage (en)
skos:notation
  • RIV/61989592:15110/10:10213205!RIV13-MSM-15110___
http://linked.open...avai/riv/aktivita
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  • Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika
  • 5
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  • 250702
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  • RIV/61989592:15110/10:10213205
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  • DESTRUCTION; CHROMOSOMES; MDC1; CANCER; CHECKPOINT; S-PHASE; NURD COMPLEX; IONIZING-RADIATION; HISTONE DEACETYLASE; DOUBLE-STRAND BREAKS (en)
http://linked.open.../riv/klicoveSlovo
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  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [9FAFA1F3B31A]
http://linked.open...i/riv/nazevZdroje
  • Journal of Cell Biology
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 190
http://linked.open...iv/tvurceVysledku
  • Bártek, Jiří
  • Lukáš, Jiří
  • Lukas, Claudia
  • Andersen, Jens
  • Danielsen, Jannie
  • Dinant, Christoffel
  • Gudjonsson, Thorkell
  • Hari, Flurina
  • Larsen, Dorthe
  • Menard, Patrice
  • Payne, Mark
  • Poinsignon, Catherine
  • Sand, Jette
  • Stucki, Manuel
http://linked.open...ain/vavai/riv/wos
  • 000281781300005
http://linked.open...n/vavai/riv/zamer
issn
  • 0021-9525
number of pages
http://bibframe.org/vocab/doi
  • 10.1083/jcb.200912135
http://localhost/t...ganizacniJednotka
  • 15110
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