About: Glycosylation Patterns of HIV-1 gp120 Depend on the Type of Expressing Cells and Affect Antibody Recognition

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About: Glycosylation Patterns of HIV-1 gp120 Depend on the Type of Expressing Cells and Affect Antibody Recognition Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Human immunodeficiency virus type 1 (HIV-1) entry is mediated by the interaction between a variably glycosylated envelope glycoprotein (gp120) and host-cell receptors. Approximately half of the molecular mass of gp120 is contributed by N-glycans, which serve as potential epitopes and may shield gp120 from immunerecognition. The role ofgp120 glycans in the hostimmune response to HIV-1 has not been comprehensively studied at the molecular level. We developed anewapproach to characterize cell specific gp120 glycosylation, the regulation of glycosylation, and the effect of variable glycosylation on antibody reactivity. A model oligomeric gp120 was expressed in different cell types, including cell lines that represent host-infected cells or cells used to produce gp120 for vaccination purposes. Human immunodeficiency virus type 1 (HIV-1) entry is mediated by the interaction between a variably glycosylated envelope glycoprotein (gp120) and host-cell receptors. Approximately half of the molecular mass of gp120 is contributed by N-glycans, which serve as potential epitopes and may shield gp120 from immunerecognition. The role ofgp120 glycans in the hostimmune response to HIV-1 has not been comprehensively studied at the molecular level. We developed anewapproach to characterize cell specific gp120 glycosylation, the regulation of glycosylation, and the effect of variable glycosylation on antibody reactivity. A model oligomeric gp120 was expressed in different cell types, including cell lines that represent host-infected cells or cells used to produce gp120 for vaccination purposes. (en)
Title	Glycosylation Patterns of HIV-1 gp120 Depend on the Type of Expressing Cells and Affect Antibody Recognition Glycosylation Patterns of HIV-1 gp120 Depend on the Type of Expressing Cells and Affect Antibody Recognition (en)
skos:prefLabel	Glycosylation Patterns of HIV-1 gp120 Depend on the Type of Expressing Cells and Affect Antibody Recognition Glycosylation Patterns of HIV-1 gp120 Depend on the Type of Expressing Cells and Affect Antibody Recognition (en)
skos:notation	RIV/61989592:15110/10:10213111!RIV11-MSM-15110___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(ME 875), Z(MSM6198959223)
http://linked.open...iv/cisloPeriodika	27
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	RAŠKA, Milan Zachová, Kateřina Czerneková, Lýdie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	260854
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/10:10213111
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Recognition; Antibody; gp120; HIV-1; Glycosylation Patterns (en)
http://linked.open.../riv/klicoveSlovo	Recognition HIV-1 Antibody Glycosylation Patterns gp120
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[351AC8F8AF78]
http://linked.open...i/riv/nazevZdroje	JOURNAL OF BIOLOGICAL CHEMISTRY
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	17 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20875
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	258
http://linked.open...iv/tvurceVysledku	Novák, Jan Zachová, Kateřina Raška, Milan Czerneková, Lýdie Vrbková, Jana Takahashi, Kazuo Jančová, Dagmar
http://linked.open...n/vavai/riv/zamer	Nové možnosti diagnostiky a imunomodulace u infekčních onemocnění a imunopatologických stavů
issn	0021-9258
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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