About: Involvement of microRNAs in physiological and pathological processes in the lung

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	To date, at least 900 different microRNA (miRNA) genes have been discovered in the human genome. These short, single-stranded RNA molecules originate from larger precursor molecules that fold to produce hairpin structures, which are subsequently processed by ribonucleases Drosha/Pasha and Dicer to form mature miRNAs. MiRNAs play role in the posttranscriptional regulation of about one third of human genes, mainly via degradation of target mRNAs. Whereas the target mRNAs are often involved in the regulation of diverse physiological processes rating from developmental timing to apoptosis, miRNAs have a strong potential to regulate fundamental biological processes also in the lung compartment. However, the knowledge of the role of miRNAs in physiological and pathological conditions in the lung is still limited. This review, therefore, summarizes current knowledge of the mechanism, function of miRNAs and thein contribution to lung development and homeostasis. To date, at least 900 different microRNA (miRNA) genes have been discovered in the human genome. These short, single-stranded RNA molecules originate from larger precursor molecules that fold to produce hairpin structures, which are subsequently processed by ribonucleases Drosha/Pasha and Dicer to form mature miRNAs. MiRNAs play role in the posttranscriptional regulation of about one third of human genes, mainly via degradation of target mRNAs. Whereas the target mRNAs are often involved in the regulation of diverse physiological processes rating from developmental timing to apoptosis, miRNAs have a strong potential to regulate fundamental biological processes also in the lung compartment. However, the knowledge of the role of miRNAs in physiological and pathological conditions in the lung is still limited. This review, therefore, summarizes current knowledge of the mechanism, function of miRNAs and thein contribution to lung development and homeostasis. (en)
Title	Involvement of microRNAs in physiological and pathological processes in the lung Involvement of microRNAs in physiological and pathological processes in the lung (en)
skos:prefLabel	Involvement of microRNAs in physiological and pathological processes in the lung Involvement of microRNAs in physiological and pathological processes in the lung (en)
skos:notation	RIV/61989592:15110/10:10212720!RIV11-MZ0-15110___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(NS10260), P(NS10267), P(NT11117), S
http://linked.open...iv/cisloPeriodika	159
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Petřek, Martin Tománková, Tereza Kriegová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	264876
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/10:10212720
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lung disorders; lung development; biogenesis; miRNA (en)
http://linked.open.../riv/klicoveSlovo	lung development biogenesis miRNA lung disorders
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[498D422B37EC]
http://linked.open...i/riv/nazevZdroje	Respiratory Research
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of mediators of fibrotic processes in patients with diffuse lung diseases and their clinical application Individual susceptibility to periprosthetic joint infection: a role of variants in genes coding for innate immunity receptors and for chemotactic / proinflammatory cytokines Expression profiling of immunological biomarkers in different stages of chronic obstructive pulmonary disease
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Petřek, Martin KRIEGOVÁ, Eva TOMÁNKOVÁ, Tereza
issn	1465-9921
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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