About: Effect of levodopa and entacapone treatment on plasma homocysteine levels in Parkinson's disease patients     Goto   Sponge   NotDistinct   Permalink

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  • Homocysteine (HCY)is a risk factor for vascular diseases, cognitive impairment and dementia. Vascular diseases and cognitive impairment worsen the prognosis of Parkinson's disease. Risk of their occurence is advisable to minimize. The mechanism underlying elevated plasma HCY level is the O-methylation of levodopa. This reaction is catalyzed by the enzyme catechol-O-methyltransferase (COMT) and requires S-adenosylmethionine as the methyl donor for the production of S-adenosylhomocysteine, which is rapidly hydrolyzed to HCY. Elevated plasma HCY levels were found in PD patients treated with levodopa. Some animal studies shows., that addition of COMT inhibitors to levodopa should eliminate levodopa induced hyperhomocysteinemia (HHCY). Some of recent retrospective studies confirmed fact, but some of them did not.
  • Homocysteine (HCY)is a risk factor for vascular diseases, cognitive impairment and dementia. Vascular diseases and cognitive impairment worsen the prognosis of Parkinson's disease. Risk of their occurence is advisable to minimize. The mechanism underlying elevated plasma HCY level is the O-methylation of levodopa. This reaction is catalyzed by the enzyme catechol-O-methyltransferase (COMT) and requires S-adenosylmethionine as the methyl donor for the production of S-adenosylhomocysteine, which is rapidly hydrolyzed to HCY. Elevated plasma HCY levels were found in PD patients treated with levodopa. Some animal studies shows., that addition of COMT inhibitors to levodopa should eliminate levodopa induced hyperhomocysteinemia (HHCY). Some of recent retrospective studies confirmed fact, but some of them did not. (en)
Title
  • Effect of levodopa and entacapone treatment on plasma homocysteine levels in Parkinson's disease patients
  • Effect of levodopa and entacapone treatment on plasma homocysteine levels in Parkinson's disease patients (en)
skos:prefLabel
  • Effect of levodopa and entacapone treatment on plasma homocysteine levels in Parkinson's disease patients
  • Effect of levodopa and entacapone treatment on plasma homocysteine levels in Parkinson's disease patients (en)
skos:notation
  • RIV/61989592:15110/09:10224581!RIV12-MSM-15110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 15
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 312151
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/09:10224581
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • L-DOPA; entacapone; Parkinson's disease; homocysteine (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [72B463EC6EA9]
http://linked.open...i/riv/nazevZdroje
  • Parkinsonism and Related Disorders
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 2009
http://linked.open...iv/tvurceVysledku
  • Langová, Kateřina
  • Kaňovský, Petr
  • Hluštík, Petr
  • Nevrlý, Martin
  • Vranová, Hana
issn
  • 1353-8020
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
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