About: Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis

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About: Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Objective: To characterize the differences in various risk factors for atherosclerosis between individuals with apoB higher (H) and lower (L) than predicted from regression equation apoB vs LDL-C. Methods: We evaluated 391 dyslipidemic subjects not treated with hypolipidemic drugs. The measured parameters included lipid profile, apolipoproteins A-1 and B, markers of insulin resistance and inflammation/hemostasis. Results: Correlation coefficient between apoB and LDL-C was 0.9 (p<0.0001). Individuals with H apoB compared to L apoB had significantly higher sex and age adjusted BMI, waist circumference, insulin, HOMA (fasting insulinglucose/22,5), C-peptide, proinsulin, PAI-1, sICAM-1, sVCAM-1, t-PA, vWF, frequency of metabolic syndrome and lower values of TD, LDL-C and HDL-C (p<0,05 to <0.001 for all parameters). Conclusion: individuals with apoB higher than predicted by their LDL-C levels are more insulin resistant and have more atherogenic risk profile. Thus, at least for dyslipidemic patient Objective: To characterize the differences in various risk factors for atherosclerosis between individuals with apoB higher (H) and lower (L) than predicted from regression equation apoB vs LDL-C. Methods: We evaluated 391 dyslipidemic subjects not treated with hypolipidemic drugs. The measured parameters included lipid profile, apolipoproteins A-1 and B, markers of insulin resistance and inflammation/hemostasis. Results: Correlation coefficient between apoB and LDL-C was 0.9 (p<0.0001). Individuals with H apoB compared to L apoB had significantly higher sex and age adjusted BMI, waist circumference, insulin, HOMA (fasting insulinglucose/22,5), C-peptide, proinsulin, PAI-1, sICAM-1, sVCAM-1, t-PA, vWF, frequency of metabolic syndrome and lower values of TD, LDL-C and HDL-C (p<0,05 to <0.001 for all parameters). Conclusion: individuals with apoB higher than predicted by their LDL-C levels are more insulin resistant and have more atherogenic risk profile. Thus, at least for dyslipidemic patient (en)
Title	Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis (en)
skos:prefLabel	Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis Apolipoprotein B versus LDL-cholesterol: Association with other risk factors for atherosclerosis (en)
skos:notation	RIV/61989592:15110/09:00009786!RIV10-MZ0-15110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9068)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	VAVERKOVÁ, Helena KARÁSEK, David Halenka, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	303709
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/09:00009786
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apolipoprotein B; LDL-cholesterol; dyslipidemia; cardiometabolic risk; insulin resistance; metabolic syndrome; apolipoprotein B targets; guidelines (en)
http://linked.open.../riv/klicoveSlovo	apolipoprotein B LDL-cholesterol apolipoprotein B targets guidelines insulin resistance metabolic syndrome dyslipidemia cardiometabolic risk
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F87094A4DFC6]
http://linked.open...i/riv/nazevZdroje	Clinical Biochemistry
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Dyslipidemia classification based on concentration of apolipoprotein B and triglycerides. Association of dyslipidemic phenotypes with indices of insulin resistance, inflammation and thrombosis, subclinical and clinical atherosclerosis and DNA markers.
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	42
http://linked.open...iv/tvurceVysledku	Vaverková, Helena Halenka, Milan Karásek, David Novotný, Dalibor Lukeš, Jiří Frohlich, Jiří Jackuliaková, Dagmar
issn	0009-9120
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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