About: Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris and hypertension

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About: Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris and hypertension Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of our work was to found if MCP-1 -2518 (A/G) single nucleotide polymorfism (SNP) influences anyway the serum concentrations of hsCRP (high sensitive CRP) both in patiens suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP) and hypertension (HT) and in control group of healthy subjects. First, we estimated the serum levels of hsCRP. We found that patients with AP had significantly higher serum level of hsCRP than both control group of healthy subjects (P = 0.043) and IHD patients without AP (P = 0.026). The presence of the mutant G allele statistically significantly correlated with the higher serum levels of hsCRP in patients with IHD (P = 0.016), AP (P = 0.004) and HT (P = 0.013). Higher correlations were found in men (AP: P = 0.019; HT: P = 0.047). In all cases the highest levels of hsCRP were found both in patients and healthy controls with homozygous GG genotype. The aim of our work was to found if MCP-1 -2518 (A/G) single nucleotide polymorfism (SNP) influences anyway the serum concentrations of hsCRP (high sensitive CRP) both in patiens suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP) and hypertension (HT) and in control group of healthy subjects. First, we estimated the serum levels of hsCRP. We found that patients with AP had significantly higher serum level of hsCRP than both control group of healthy subjects (P = 0.043) and IHD patients without AP (P = 0.026). The presence of the mutant G allele statistically significantly correlated with the higher serum levels of hsCRP in patients with IHD (P = 0.016), AP (P = 0.004) and HT (P = 0.013). Higher correlations were found in men (AP: P = 0.019; HT: P = 0.047). In all cases the highest levels of hsCRP were found both in patients and healthy controls with homozygous GG genotype. (en)
Title	Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris and hypertension Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris and hypertension (en)
skos:prefLabel	Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris and hypertension Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris and hypertension (en)
skos:notation	RIV/61989592:15110/09:00009655!RIV10-MSM-15110___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(ME 856), S, Z(MSM6198959205)
http://linked.open...iv/cisloPeriodika	390951
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Petřek, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	304248
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/09:00009655
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CRP; MCP-1 polymorphism; ischemic heart disease; angina pectoris; hypertension; inflammation. (en)
http://linked.open.../riv/klicoveSlovo	hypertension - ischaemic heart disease - cardiac failure - vitamin D ischemic heart disease MCP-1 polymorphism inflammation. CRP angina pectoris
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CF9D3D129785]
http://linked.open...i/riv/nazevZdroje	Mediators of Inflammation
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20856
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	2009
http://linked.open...iv/tvurceVysledku	Mrázek, František Petřek, Martin Petřková, Jana Bucová, Mária Bernadič, Marián Lietava, Ján Penz, Peter
http://linked.open...n/vavai/riv/zamer	Studies of genes and molecular mechanisms involved in regulation of hematopoiesis, their clinical impact and targeted treatment
issn	0962-9351
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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