About: Cyclosporin A sensitises Bcr-Abl positive cells to imatinib mesylate independently of P-glykoprotein expression.

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About: Cyclosporin A sensitises Bcr-Abl positive cells to imatinib mesylate independently of P-glykoprotein expression. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The effect of cyclosporin A (CsA) on imatinib treated Bcr-Abl positive K562 cells was studied. Similarly to other authors we found that imatinib induced apoptosis and erythroid differentiation in K562 cells. While its low concentrations induced predominantly erythroid differentiation, higher concentrations induced apoptosis. We found that CsA significantly potentiated cytotoxic effects of imatinib. A detailed analysis revealed that CsA shifted the balance between differentiation and apoptosis in favour of apoptosis. Our findings indicated that the observed effect of CsA was mediated neither through inhibition of ERK1/2 (extracellular signal-regulated kinases 1/2), nor through inhibition of p38 MAPK. We further observed that CsA might sensitise cells to apoptosis due to a changed cellular redox status as combined treatment of cells with imatinib and CsA resulted in a dramatic decrease of the ratio between reduced (GSH) and oxidised (GSSG) glutathione GSH/GSSG and in a significant suppression of thiored The effect of cyclosporin A (CsA) on imatinib treated Bcr-Abl positive K562 cells was studied. Similarly to other authors we found that imatinib induced apoptosis and erythroid differentiation in K562 cells. While its low concentrations induced predominantly erythroid differentiation, higher concentrations induced apoptosis. We found that CsA significantly potentiated cytotoxic effects of imatinib. A detailed analysis revealed that CsA shifted the balance between differentiation and apoptosis in favour of apoptosis. Our findings indicated that the observed effect of CsA was mediated neither through inhibition of ERK1/2 (extracellular signal-regulated kinases 1/2), nor through inhibition of p38 MAPK. We further observed that CsA might sensitise cells to apoptosis due to a changed cellular redox status as combined treatment of cells with imatinib and CsA resulted in a dramatic decrease of the ratio between reduced (GSH) and oxidised (GSSG) glutathione GSH/GSSG and in a significant suppression of thiored (en)
Title	Cyclosporin A sensitises Bcr-Abl positive cells to imatinib mesylate independently of P-glykoprotein expression. Cyclosporin A sensitises Bcr-Abl positive cells to imatinib mesylate independently of P-glykoprotein expression. (en)
skos:prefLabel	Cyclosporin A sensitises Bcr-Abl positive cells to imatinib mesylate independently of P-glykoprotein expression. Cyclosporin A sensitises Bcr-Abl positive cells to imatinib mesylate independently of P-glykoprotein expression. (en)
skos:notation	RIV/61989592:15110/09:00009620!RIV10-MSM-15110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR9482), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	MLEJNEK, Petr DOLEŽEL, Petr Frydrych, Ivo
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	308782
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/09:00009620
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Differentiation; Apoptosis; K562 cells; Glutathione; Thioredoxin reductase (en)
http://linked.open.../riv/klicoveSlovo	Thioredoxin reductase Apoptosis Differentiation K562 cells Glutathione
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[8FDD5C859CC9]
http://linked.open...i/riv/nazevZdroje	Toxicology in Vitro
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	P-glycoprotein and its possible contribution to development of resistance to Imatinib in Bcr-Abl expressing cells
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Doležel, Petr Mlejnek, Petr Frydrych, Ivo
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0887-2333
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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