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rdf:type
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Description
| - Differences in expression of mRNA of genes regulating lipid and drug metabolism between hereditary hypertriglyceridemic rats (HHTg, accepted model of metabolic syndrome) and healthy Wistar-Kyoto (WKY) rats were studied. Also, differences in expression due to intake of high cholesterol diet (1% w/w) were determined to investigate possible differences in response of the WKY and HHTg rats to increased intake of dietary cholesterol. Levels of ATP-binding cassette transporters (ABCG5, ABCG8), fatty acid synthase (FAS) and cytochrome P450 (CYP2C11) mRNA were significantly lower in HHTg rats on standard laboratory diet; in contrary, CYP7A1, CYP2C6 and CYP2B2 gene expression was significantly higher. The WKY rats responded to high cholesterol diet by an increase in expression of mRNAs for sterol regulatory element binding protein (SREBP1c), CYP2B2 and CYP7A1; lower expression was found in the FAS, ABCG5, ABCG8, CYP4A1, CYP4A2 and acyl-CoA oxidase. HHTg rats responded to cholesterol intake in a similar manner,
- Differences in expression of mRNA of genes regulating lipid and drug metabolism between hereditary hypertriglyceridemic rats (HHTg, accepted model of metabolic syndrome) and healthy Wistar-Kyoto (WKY) rats were studied. Also, differences in expression due to intake of high cholesterol diet (1% w/w) were determined to investigate possible differences in response of the WKY and HHTg rats to increased intake of dietary cholesterol. Levels of ATP-binding cassette transporters (ABCG5, ABCG8), fatty acid synthase (FAS) and cytochrome P450 (CYP2C11) mRNA were significantly lower in HHTg rats on standard laboratory diet; in contrary, CYP7A1, CYP2C6 and CYP2B2 gene expression was significantly higher. The WKY rats responded to high cholesterol diet by an increase in expression of mRNAs for sterol regulatory element binding protein (SREBP1c), CYP2B2 and CYP7A1; lower expression was found in the FAS, ABCG5, ABCG8, CYP4A1, CYP4A2 and acyl-CoA oxidase. HHTg rats responded to cholesterol intake in a similar manner, (en)
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Title
| - Differences in hepatic expression of genes involved in lipid homeostasis between hereditary hypertriglyceridemic rats and healthy Wistar rats and in their response to dietary cholesterol.
- Differences in hepatic expression of genes involved in lipid homeostasis between hereditary hypertriglyceridemic rats and healthy Wistar rats and in their response to dietary cholesterol. (en)
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skos:prefLabel
| - Differences in hepatic expression of genes involved in lipid homeostasis between hereditary hypertriglyceridemic rats and healthy Wistar rats and in their response to dietary cholesterol.
- Differences in hepatic expression of genes involved in lipid homeostasis between hereditary hypertriglyceridemic rats and healthy Wistar rats and in their response to dietary cholesterol. (en)
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skos:notation
| - RIV/61989592:15110/09:00009561!RIV10-MSM-15110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA305/09/1177), P(OC09004), V, Z(MSM6198959216)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/09:00009561
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - HHTg rats; Wistar-Kyoto rats; expression (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Food and Chemical Toxicology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Marková, I.
- Anzenbacher, Pavel
- Orolin, Jan
- Večeřa, Rostislav
- Zachařová, Alice
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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