About: PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS

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About: PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Periodontitis is a chronic disease associated with inflammation of the tooth-supporting tissues. The inflammation is initiated by a group of gram-negative anaerobic bacteria. These express a number of irritating factors including a lipopolysaccharide (LPS), which plays a key role in periodontal disease development. Plant extracts with anti-inflammatory and anti-microbial properties have been shown to inhibit bacterial plaque formation and thus prevent chronic gingivitis. In this study we tested effects of Prunella vulgaris L. extract (PVE; 5, 10, 25 ?g/ml) and its component rosmarinic acid (RA; 1 ?g/ml) on LPS-induced oxidative damage and inflammation in human gingival fibroblasts. PVE and RA reduced reactive oxygen species (ROS) production, intracellular glutathione (GSH) depletion as well as lipid peroxidation in LPS-treated cells. Treatment with PVE and RA also inhibited LPS-induced up-regulation of interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-α (TNF) and suppr Periodontitis is a chronic disease associated with inflammation of the tooth-supporting tissues. The inflammation is initiated by a group of gram-negative anaerobic bacteria. These express a number of irritating factors including a lipopolysaccharide (LPS), which plays a key role in periodontal disease development. Plant extracts with anti-inflammatory and anti-microbial properties have been shown to inhibit bacterial plaque formation and thus prevent chronic gingivitis. In this study we tested effects of Prunella vulgaris L. extract (PVE; 5, 10, 25 ?g/ml) and its component rosmarinic acid (RA; 1 ?g/ml) on LPS-induced oxidative damage and inflammation in human gingival fibroblasts. PVE and RA reduced reactive oxygen species (ROS) production, intracellular glutathione (GSH) depletion as well as lipid peroxidation in LPS-treated cells. Treatment with PVE and RA also inhibited LPS-induced up-regulation of interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-α (TNF) and suppr (en)
Title	PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS (en)
skos:prefLabel	PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS PRUNELLA VULGARIS EXTRACT AND ROSMARINIC ACID SUPPRESS LIPOPOLYSACCHARIDE-INDUCED ALTERATION IN HUMAN GINGIVAL FIBROBLASTS (en)
skos:notation	RIV/61989592:15110/09:00009496!RIV10-MSM-15110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šimánek, Vilím Rajnochová Svobodová, Alena Ulrichová, Jitka Galandáková, Adéla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	337470
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/09:00009496
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antioxidant; anti-inflammatory activity; reactive oxygen species; cytokine (en)
http://linked.open.../riv/klicoveSlovo	antioxidant reactive oxygen species anti-inflammatory activity cytokine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[8F4BFE1867D0]
http://linked.open...i/riv/nazevZdroje	Toxicology in Vitro
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Ulrichová, Jitka Šimánek, Vilím Svobodová, Alena Zdařilová, Adéla
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0887-2333
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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