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  • An HPLC procedure for the determination of lamotrigine (LAM) simultaneously with other antiepileptic drugs, primidone (PD), phenobarbital (PB), phenytoin (DPH), carbamazepine (CMZ), and two active metabolites 2-phenyl-2-ethyl-malonamide (PEMA) and 10,11-dihydro-10,11-epoxycarbamazepine (EPO) was developed and validated. Within-day CV% and between-day CV% were within 10%. The developed HPLC method can be used for routine therapeutic drug monitoring both in children and adults.
  • An HPLC procedure for the determination of lamotrigine (LAM) simultaneously with other antiepileptic drugs, primidone (PD), phenobarbital (PB), phenytoin (DPH), carbamazepine (CMZ), and two active metabolites 2-phenyl-2-ethyl-malonamide (PEMA) and 10,11-dihydro-10,11-epoxycarbamazepine (EPO) was developed and validated. Within-day CV% and between-day CV% were within 10%. The developed HPLC method can be used for routine therapeutic drug monitoring both in children and adults. (en)
Title
  • Simultaneous determination of antiepileptic drugs and two active metabolites by HPLC
  • Simultaneous determination of antiepileptic drugs and two active metabolites by HPLC (en)
skos:prefLabel
  • Simultaneous determination of antiepileptic drugs and two active metabolites by HPLC
  • Simultaneous determination of antiepileptic drugs and two active metabolites by HPLC (en)
skos:notation
  • RIV/61989592:15110/08:10224733!RIV12-MSM-15110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, S, Z(MSM0021627502)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 394937
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/08:10224733
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • antiepileptic; HPLC (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [5CB8F6E9A2ED]
http://linked.open...i/riv/nazevZdroje
  • Journal of Separation Science
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 31
http://linked.open...iv/tvurceVysledku
  • Grundmann, Milan
  • Fischer, J.
  • Budáková, L.
  • Brozmanová, H.
http://linked.open...n/vavai/riv/zamer
issn
  • 1615-9306
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
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