About: Influence of Circulating Cell-derived Microparticles on Thrombin Generation in Thrombophilia Patients     Goto   Sponge   NotDistinct   Permalink

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  • Thrombin generation test (TGT) was developed several years ago to mimic physiological coagulation. It can be used in many applications including assessment of thrombophilia state. We used this test for observation of influence of cell-derived microparticles, platelet (PMP) and endothelias (EMP), on thrombin generation in patients with good defined thrombophilia state such as Factor V Leiden (FVL) mutation. We evaluated thrombin generation parametres in samples with and without microparticles and determined their influence on clinical course of thrombophilia state in group of 25 carriers of heterozygous form of FVL. We found significant correlation between amount of generated thrombin and microparticles level. Patients with higher thrombin generation were more often affected by thrombotic complication.
  • Thrombin generation test (TGT) was developed several years ago to mimic physiological coagulation. It can be used in many applications including assessment of thrombophilia state. We used this test for observation of influence of cell-derived microparticles, platelet (PMP) and endothelias (EMP), on thrombin generation in patients with good defined thrombophilia state such as Factor V Leiden (FVL) mutation. We evaluated thrombin generation parametres in samples with and without microparticles and determined their influence on clinical course of thrombophilia state in group of 25 carriers of heterozygous form of FVL. We found significant correlation between amount of generated thrombin and microparticles level. Patients with higher thrombin generation were more often affected by thrombotic complication. (en)
Title
  • Influence of Circulating Cell-derived Microparticles on Thrombin Generation in Thrombophilia Patients
  • Influence of Circulating Cell-derived Microparticles on Thrombin Generation in Thrombophilia Patients (en)
skos:prefLabel
  • Influence of Circulating Cell-derived Microparticles on Thrombin Generation in Thrombophilia Patients
  • Influence of Circulating Cell-derived Microparticles on Thrombin Generation in Thrombophilia Patients (en)
skos:notation
  • RIV/61989592:15110/08:00009735!RIV10-MSM-15110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NR9282), S
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
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  • 372060
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/08:00009735
http://linked.open...riv/jazykVysledku
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  • thrombin generation test; microparticles; thrombophilia (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [D47398BDF26A]
http://linked.open...v/mistoKonaniAkce
  • 20th International Congress on Thrombosis
http://linked.open...i/riv/mistoVydani
  • Ahtens, Greece
http://linked.open...i/riv/nazevZdroje
  • Proceedings of the 20th International Congress on Thrombosis
http://linked.open...in/vavai/riv/obor
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http://linked.open...vavai/riv/projekt
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  • Krčová, Věra
  • Procházková, Jana
  • Slavík, Luděk
  • Hluší, Antonín
  • Úlehlová, Jana
  • Ježáková, Jarmila
  • Klusová, N.
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
number of pages
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  • Liapis, CD; Antonios, HN
https://schema.org/isbn
  • 978-88-7587-423-0
http://localhost/t...ganizacniJednotka
  • 15110
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