About: SUCCESSFUL CHILDBIRTH IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH IMATINIB MESYLATE DURING EARLY PREGNANCY

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About: SUCCESSFUL CHILDBIRTH IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH IMATINIB MESYLATE DURING EARLY PREGNANCY Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aims: To report a case of successful pregnancy in a patient with chronic myelogenous leukemia treated with imatinib mesylate for the fi rst 4 months of pregnancy. Results: Imatinib mesylate is potentially teratogenic and its use during pregnancy in humans can lead to abortion or development of fetal abnormalities in nearly 40% of fully reported cases. We report a case of a 28-year-old woman who delivered a healthy child of normal weight after having been treated with imatinib for Ph1-positive CML during the fi rst four months of her pregnancy. She refused advocated interruption and for the rest of the pregnancy was treated with interferon. The treatment was associated with a rapid 2-log increase in the leukemia clone measured by the real-time polymerase chain reaction. Reintroduction of imatinib after delivery resulted in achievement of the complete cytogenetic response again. Conclusions: We discuss possible strategies for successful management of pregnancy in CML patients treated with imat Aims: To report a case of successful pregnancy in a patient with chronic myelogenous leukemia treated with imatinib mesylate for the fi rst 4 months of pregnancy. Results: Imatinib mesylate is potentially teratogenic and its use during pregnancy in humans can lead to abortion or development of fetal abnormalities in nearly 40% of fully reported cases. We report a case of a 28-year-old woman who delivered a healthy child of normal weight after having been treated with imatinib for Ph1-positive CML during the fi rst four months of her pregnancy. She refused advocated interruption and for the rest of the pregnancy was treated with interferon. The treatment was associated with a rapid 2-log increase in the leukemia clone measured by the real-time polymerase chain reaction. Reintroduction of imatinib after delivery resulted in achievement of the complete cytogenetic response again. Conclusions: We discuss possible strategies for successful management of pregnancy in CML patients treated with imat (en)
Title	SUCCESSFUL CHILDBIRTH IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH IMATINIB MESYLATE DURING EARLY PREGNANCY SUCCESSFUL CHILDBIRTH IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH IMATINIB MESYLATE DURING EARLY PREGNANCY (en)
skos:prefLabel	SUCCESSFUL CHILDBIRTH IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH IMATINIB MESYLATE DURING EARLY PREGNANCY SUCCESSFUL CHILDBIRTH IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH IMATINIB MESYLATE DURING EARLY PREGNANCY (en)
skos:notation	RIV/61989592:15110/08:00009701!RIV10-MSM-15110___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM6198959205)
http://linked.open...iv/cisloPeriodika	152
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šantavá, Alena Procházka, Martin Vondráková, Jana Skoumalová, Ivana Faber, Edgar INDRÁK, Karel Rohoň, Peter Rožmanová, Šárka Jarošová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	398297
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/08:00009701
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Chronic myelogenous leukemia; Pregnancy; Imatinib mesylate; Interferon alpha (en)
http://linked.open.../riv/klicoveSlovo	Pregnancy Interferon alpha Imatinib mesylate Chronic myelogenous leukemia
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[2D19F47EC55C]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	2008
http://linked.open...iv/tvurceVysledku	Faber, Edgar Indrák, Karel Jarošová, Marie Procházka, Martin Rohoň, Peter Skoumalová, Ivana Vondráková, Jana Rožmanová, Šárka Šantavá, Alena
http://linked.open...n/vavai/riv/zamer	Studies of genes and molecular mechanisms involved in regulation of hematopoiesis, their clinical impact and targeted treatment
issn	1213-8118
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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