About: Aurora Kinases: Structure, Functions and Their Association with Cancer.

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About: Aurora Kinases: Structure, Functions and Their Association with Cancer. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: Aurora kinases are a recently discovered family of kinases (A, B & C) consisting of highly conserved serine\threonine protein kinases found to be involved in multiple mitotic events: regulation of spindle assembly checkpoint pathway, function of centrosomes and cytoskeleton, and cytokinesis. Aberrant expression of Aurora kinases may lead to cancer. For this reason the Aurora kinases are potential targets in the treatment of cancer. In this review we discuss the biology of these kinases: structure, function, regulation and association with cancer. Methods and Results: A literature search. Conclusion: Many of the multiple functions of mitosis are mediated by the Aurora kinases. Their aberrant expression can lead to the deregulation of cell division and cancer. For this reason, the Aurora kinases are currently one of the most interesting targets for cancer therapy. Some Aurora kinase inhibitors in the clinic have proven eff ectively on a wide range of tumor types. The clinical data are Background: Aurora kinases are a recently discovered family of kinases (A, B & C) consisting of highly conserved serine\threonine protein kinases found to be involved in multiple mitotic events: regulation of spindle assembly checkpoint pathway, function of centrosomes and cytoskeleton, and cytokinesis. Aberrant expression of Aurora kinases may lead to cancer. For this reason the Aurora kinases are potential targets in the treatment of cancer. In this review we discuss the biology of these kinases: structure, function, regulation and association with cancer. Methods and Results: A literature search. Conclusion: Many of the multiple functions of mitosis are mediated by the Aurora kinases. Their aberrant expression can lead to the deregulation of cell division and cancer. For this reason, the Aurora kinases are currently one of the most interesting targets for cancer therapy. Some Aurora kinase inhibitors in the clinic have proven eff ectively on a wide range of tumor types. The clinical data are (en) Aurora kinázy jsou nedávno objevenou rodinou kináz (A, B & C) skládající se z vysoce zachovaného serin/threonin proteinových kináz, které byly nalezeny, aby byl zahrnuty v mnoha miotických záležitostech: regulace a kontrola centra růstu, průběh, funkce centrosomu a cytoskeletonu a cytokinézy. (cs)
Title	Aurora Kinases: Structure, Functions and Their Association with Cancer. Aurora kinázy: struktura, funkce a jejich spojitost s rakovinou. (cs) Aurora Kinases: Structure, Functions and Their Association with Cancer. (en)
skos:prefLabel	Aurora Kinases: Structure, Functions and Their Association with Cancer. Aurora kinázy: struktura, funkce a jejich spojitost s rakovinou. (cs) Aurora Kinases: Structure, Functions and Their Association with Cancer. (en)
skos:notation	RIV/61989592:15110/08:00007181!RIV09-MSM-15110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC07017), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Džubák, Petr Hajdúch, Marián Kollareddy, Madhusudhan Reddy
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	357331
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/08:00007181
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Aurora kinases; Serine; threonine; Spindle; Centrosomes; Cytoskeleton; Cytokinesis; Oncogenes (en)
http://linked.open.../riv/klicoveSlovo	Cytoskeleton Cytokinesis Aurora kinases Spindle Serine Centrosomes Oncogenes threonine
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[D4CD5B527B00]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Oncoproteomics Centre
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	152
http://linked.open...iv/tvurceVysledku	Džubák, Petr Hajdúch, Marián Kollareddy, Madhusudhan Reddy Zheleva, Daniella
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1213-8118
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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