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| Description
| - Background: Discovery of uncoupling protein 2 (UCP2) in 1997 and demonstration of its wide tissue expression has triggered an important question about controlled oxidative phosphorylation uncoupling and the physiological function of this process. Uncoupling protein 2 (UcP2) is a mitochondrial protein that can infl uence the mitochondrial membrane potential and hence the production of reactive oxygen species by mitochondria. It is also thought to be involved in apoptotic signaling pathways and it has been suggested to be important in cardio- and neuroprotection. Methods and results: We examined the recent literature (2003?2007) in the MedLine database for evidence linking p38, one of the stress-related protein kinases, with modulation of UCP2 expression in the heart. While two reports clearly demonstrate p38 as down-regulating UcP2 expression, only circumstantial evidence exists for cardiomyocytes. Confl icting results on p38-regulated cardiomyocyte survival after ischemia leave an open venue f
- Background: Discovery of uncoupling protein 2 (UCP2) in 1997 and demonstration of its wide tissue expression has triggered an important question about controlled oxidative phosphorylation uncoupling and the physiological function of this process. Uncoupling protein 2 (UcP2) is a mitochondrial protein that can infl uence the mitochondrial membrane potential and hence the production of reactive oxygen species by mitochondria. It is also thought to be involved in apoptotic signaling pathways and it has been suggested to be important in cardio- and neuroprotection. Methods and results: We examined the recent literature (2003?2007) in the MedLine database for evidence linking p38, one of the stress-related protein kinases, with modulation of UCP2 expression in the heart. While two reports clearly demonstrate p38 as down-regulating UcP2 expression, only circumstantial evidence exists for cardiomyocytes. Confl icting results on p38-regulated cardiomyocyte survival after ischemia leave an open venue f (en)
- Profil: Objev uncoupling proteinu 2 (UCP2) v roce 1997 a demonstrace jeho exprese v mnoha tkáních vzbudila důležitou otázku o kontrolovaném odpřažení oxidativní fosforylace a fyziologické funkci tohoto procesu. Uncoupling protein (UCP2) je mitochondriální protein, který může ovlivnit mitochondriální membránový potenciál a vyvolat produkci reaktivních kyslíkových radikálů mitochondriemi. Zdá se, že UCP2 je zapojen do apoptotické signální dráhy a je důležitý v kardio- a neuroprotekci. Metody a výsledky: Pro důkaz spojení p38, jedné z proteinkináz související se stresem, s modulací exprese UCP2 v srdci jsme prověřili současnou literaturu (2003-2007) v databázi MedLine. Zatímco dvě studie jasně ukazují p38 jako regulátor snižující expresi UCP2, pro kardiomyocyty existují pouze nepřímé důkazy. Protikladné závěry o přežití kardiomyocytů po ischemii regulované p38 vedou k otevřenému místu pro hypotézu o odlišné regulaci exprese proteinu, zahrnující UCP2. Shrnutí: Ke zhodnocení důkazů spojení UCP2 a jeh (cs)
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| Title
| - Modulation of UCP2 expression by p38 - a link to cardioprotection
- Modulace exprese UCP2 p38 - souvislost s kardioprotekcí (cs)
- Modulation of UCP2 expression by p38 - a link to cardioprotection (en)
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| skos:prefLabel
| - Modulation of UCP2 expression by p38 - a link to cardioprotection
- Modulace exprese UCP2 p38 - souvislost s kardioprotekcí (cs)
- Modulation of UCP2 expression by p38 - a link to cardioprotection (en)
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| skos:notation
| - RIV/61989592:15110/08:00006994!RIV09-MSM-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA303/08/0658), Z(MSM6198959216)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/08:00006994
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Mitochondria; Oxidative phosphorylation; Uncoupling; Mitogen-activated protein kinase; Reactive oxygen species (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Modrianský, Martin
- Valoušková, Eva
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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