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| Description
| - BACKGROUND: 2-chloro-N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA) the A3 adenosine receptor (A3AR) agonist has been implicated in modulation of cell proliferation and cell death. Effects of Cl-IB-MECA strongly depend on the concentration used. Thus, nanomolar concentrations of Cl-IB-MECA stimulate cell proliferation and protect cells from death in some experimental models. On the other hand, micromolar concentrations of Cl-IB-MECA are cytotoxic and induce apoptosis itself. Interestingly, antagonistic effects of Cl-IB-MECA were attributed to the same signalling pathway, which is triggered upon ligation of A3AR. We studied cytotoxic effects of Cl-IB-MECA in K562/Dox cell line, which exhibits multidrug resistance phenotype. METHODS: K562/Dox cells were derived from K562 cell line, by long-term cultivation in the presence of increasing concentration of doxorubicin. K562/Dox is resistant to doxorubicin and also to other drugs due to P-glycoprotein (ABCB1, MDR1) overexperssion. Gene
- BACKGROUND: 2-chloro-N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA) the A3 adenosine receptor (A3AR) agonist has been implicated in modulation of cell proliferation and cell death. Effects of Cl-IB-MECA strongly depend on the concentration used. Thus, nanomolar concentrations of Cl-IB-MECA stimulate cell proliferation and protect cells from death in some experimental models. On the other hand, micromolar concentrations of Cl-IB-MECA are cytotoxic and induce apoptosis itself. Interestingly, antagonistic effects of Cl-IB-MECA were attributed to the same signalling pathway, which is triggered upon ligation of A3AR. We studied cytotoxic effects of Cl-IB-MECA in K562/Dox cell line, which exhibits multidrug resistance phenotype. METHODS: K562/Dox cells were derived from K562 cell line, by long-term cultivation in the presence of increasing concentration of doxorubicin. K562/Dox is resistant to doxorubicin and also to other drugs due to P-glycoprotein (ABCB1, MDR1) overexperssion. Gene (en)
- Agonista A3 adenosinového receptoru (A3AR) 2-chlor-N6-(3-jodobenzyl)-adenosin-5'-N-methyluronamid (Cl-IB-MECA) se účastní modulace procesů proliferace a buněčné smrti. Účinky Cl-IB-MECA jsou závislé na použité koncentraci. (cs)
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| Title
| - P-glycoprotein overexpression confers resistance to A3 adenosine receptor agonists 2-chloro-N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA) in human leukemia cells
- P-glycoprotein overexpression confers resistance to A3 adenosine receptor agonists 2-chloro-N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA) in human leukemia cells (en)
- Zvýšená exprese P-glykoproteinu uděluje leukemickým buňkám rezistenci vůči agonistovi A3 adenosinového receptoru (A3AR) 2-chlor-N6-(3-jodobenzyl)-adenosin-5'-N-methyluronamid (Cl-IB-MECA) (cs)
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| skos:prefLabel
| - P-glycoprotein overexpression confers resistance to A3 adenosine receptor agonists 2-chloro-N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA) in human leukemia cells
- P-glycoprotein overexpression confers resistance to A3 adenosine receptor agonists 2-chloro-N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA) in human leukemia cells (en)
- Zvýšená exprese P-glykoproteinu uděluje leukemickým buňkám rezistenci vůči agonistovi A3 adenosinového receptoru (A3AR) 2-chlor-N6-(3-jodobenzyl)-adenosin-5'-N-methyluronamid (Cl-IB-MECA) (cs)
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| skos:notation
| - RIV/61989592:15110/08:00006192!RIV09-MZ0-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/08:00006192
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - adenosine receptor agonist; human leukemia; P-glycoprotein; K562 cell line (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Doležel, Petr
- Mlejnek, Petr
- Frydrych, Ivo
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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