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| - We hypothesized that nucleic acids, free and/or complexed, filtered and/or locally released, might be entrapped in the kidneys because of the specific nucleic acid binding microbial pattern recognizing Toll-like receptors (TLRs). This hypothesis of nucleic acid binding potential was tested using paraffin sections from healthy control, SLE and transplant kidneys, which were labelled using TLR-specific rabbit or goat anti-human antibodies in immunoperoxidase staining. Normal and transplant kidneys contain some double-(TLR-3) and single-stranded RNA binding (TLR-8) receptors, but in particular double-stranded RNA binding receptor TLR-7, mostly in tubuli, whereas no DNA binding TLR-9 was found. SLE kidneys contain more TLR-3 and TLR-8 and express de novo also TLR-9, in particular in glomeruli. On the contrary, TLR-7 was relatively weak in SLE. It is concluded that kidneys have a capacity to bind nucleic acids. TLR stimulation leads to the production of tumour necrosis factor-alpha and other pro-inflammat
- We hypothesized that nucleic acids, free and/or complexed, filtered and/or locally released, might be entrapped in the kidneys because of the specific nucleic acid binding microbial pattern recognizing Toll-like receptors (TLRs). This hypothesis of nucleic acid binding potential was tested using paraffin sections from healthy control, SLE and transplant kidneys, which were labelled using TLR-specific rabbit or goat anti-human antibodies in immunoperoxidase staining. Normal and transplant kidneys contain some double-(TLR-3) and single-stranded RNA binding (TLR-8) receptors, but in particular double-stranded RNA binding receptor TLR-7, mostly in tubuli, whereas no DNA binding TLR-9 was found. SLE kidneys contain more TLR-3 and TLR-8 and express de novo also TLR-9, in particular in glomeruli. On the contrary, TLR-7 was relatively weak in SLE. It is concluded that kidneys have a capacity to bind nucleic acids. TLR stimulation leads to the production of tumour necrosis factor-alpha and other pro-inflammat (en)
- Předpokládali jsme, že nukleové kyseliny, ať už volné a/nebo v komplexech, filtrované a/nebo lokálně vzniklé, mohou být rozpoznány zachyceny specifickým toll-like receptory (TLR) rozeznávajícími mikrobiální nukleové kyseliny. Schopnost ledvinné tkáně vázat nukleové kyseliny byla ověřena na ledvinné tkáni kontrol, nemocných s lupusovou nefritidou a transplantovaných nemocných specifickými TLR protilátkami. Exprese RNA vázajících TLR-3, TLR-8 a TLR-7 byla pozorována zejména v tubulech kontrolního souboru. Dále byla zjištěna slabá pozitivita TLR-3 a TLR-7 v glomerulech a rovněž byla zachycena mírná pozitivita na viscerální části Bowmanova pouzdra u kontrol u TLR-7 a u TLR-8. Přítomnost TLR-9 nebyla vůbec detekována ve tkáni kontrolního souboru, zatímco tkáně s LN vykazovaly jeho expresi. U LN byla detekována vyšší exprese TLR-3 a TLR-8 v ledvinné tkáni, zvláště pak v distálních tubulech a Bowmanově pouzdru. Naproti tomu TLR-7 byl exprimován slaběji u lupusové nefritidy než u kontrol. Stimulace TLR vede (cs)
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| Title
| - Expression of nucleic acid binding Toll-like receptors in control, lupus and transplanted kidneys - a preliminary pilot study
- Expression of nucleic acid binding Toll-like receptors in control, lupus and transplanted kidneys - a preliminary pilot study (en)
- Exprese Toll-like receptorů vázajících nukleové kyseliny v ledvinách s lupusovou nefritidou, transplantovaných a kontrol - pilotní studie (cs)
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| skos:prefLabel
| - Expression of nucleic acid binding Toll-like receptors in control, lupus and transplanted kidneys - a preliminary pilot study
- Expression of nucleic acid binding Toll-like receptors in control, lupus and transplanted kidneys - a preliminary pilot study (en)
- Exprese Toll-like receptorů vázajících nukleové kyseliny v ledvinách s lupusovou nefritidou, transplantovaných a kontrol - pilotní studie (cs)
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| skos:notation
| - RIV/61989592:15110/08:00006067!RIV09-MZ0-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/08:00006067
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - lupus nephritis; transplanted kidney; TLR-3; TLR-7; TLR-8; TLR-9 (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Ciferská, Hana
- Heřmanová, Zuzana
- Horák, Pavel
- Tichý, Tomáš
- Zadražil, Josef
- Krejčí, Karel
- Konttinen, Yrio
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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