About: Benzodiazepines in clinical and forensic analysis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The results presented here show that despite the wellknown advantages of immunoassays in screening analysis of urine for drugs of abuse (including BZD), it is necessary to confirm practically all benzodiazepine results obtained in this way. Immunochemical screening of urine should be always followed by identification of BZD and their metabolites in urine or better in both urine and gastric contents using e.g. TLC, GC-MS and subsequent BZD confirmation/quantitation in blood, for example using GC-ECD. Only complex toxicological analysis of biological material (urine, gastric contents and blood) using immunochemical as well as chromatographical methods permits toxicological laboratories to give valid interpretation of results, thus contributing to objective evaluation of the level of intoxication in forensic as well as clinical practice. The results presented here show that despite the wellknown advantages of immunoassays in screening analysis of urine for drugs of abuse (including BZD), it is necessary to confirm practically all benzodiazepine results obtained in this way. Immunochemical screening of urine should be always followed by identification of BZD and their metabolites in urine or better in both urine and gastric contents using e.g. TLC, GC-MS and subsequent BZD confirmation/quantitation in blood, for example using GC-ECD. Only complex toxicological analysis of biological material (urine, gastric contents and blood) using immunochemical as well as chromatographical methods permits toxicological laboratories to give valid interpretation of results, thus contributing to objective evaluation of the level of intoxication in forensic as well as clinical practice. (en)
Title	Benzodiazepines in clinical and forensic analysis Benzodiazepines in clinical and forensic analysis (en)
skos:prefLabel	Benzodiazepines in clinical and forensic analysis Benzodiazepines in clinical and forensic analysis (en)
skos:notation	RIV/61989592:15110/07:10223813!RIV12-MSM-15110___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	101
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Zedníková, Kateřina Ondra, Peter
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	411545
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/07:10223813
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	GC-MS; GC-ECD; FPIA; determination; identification; benzodiazepines (en)
http://linked.open.../riv/klicoveSlovo	GC-MS identification benzodiazepines FPIA determination GC-ECD
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[2515A5146143]
http://linked.open...i/riv/nazevZdroje	Chemické listy
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	73-310
http://linked.open...iv/tvurceVysledku	Ondra, Peter Válka, Ivo Zedníková, Kateřina
issn	0009-2770
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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