About: Glucocorticoid Receptor Functions in HeLa Cells Are Perturbed by 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD)     Goto   Sponge   NotDistinct   Permalink

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Description
  • Použili jsme 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD) a dexamethason (DEX), abychom prošetřili jejich účinek na aryl uhlovodíkový receptor (AhR) a glukokortikodní receptor (GR) v HeLa buňkách. TCDD (5 nM), DEX (100 nM) a jejich kombinace snížily GR za 24 h. DEX potlačil nárůst AhR mRNA a proteinu způsobený dioxinem. Protože AhR-GR cross-talk se vyskytuje v závislosti na druhu organismu a typu buněk, ve kterých byl zkoumán, předkládaná data mohou sloužit jako základ v pochopení mechanismů ležících v pozadí vzájemných interakcí mezi AhR a GR. (cs)
  • We used 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD) and dexamethasone (DEX) to examine their effects on aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR) in HeLa cells. TCDD (5 nM), DEX (100 nM) and their combination down-regulated GR after 24 h. DEX reversed AhR mRNA increase and AhR protein decrease caused by TCDD. Since AhR-GR cross-talk occurs in cell-type and species-specific manner, the presented data may serve as the basis in the understanding of mechanisms underlying mutual interactions between AhR and GR.
  • We used 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD) and dexamethasone (DEX) to examine their effects on aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR) in HeLa cells. TCDD (5 nM), DEX (100 nM) and their combination down-regulated GR after 24 h. DEX reversed AhR mRNA increase and AhR protein decrease caused by TCDD. Since AhR-GR cross-talk occurs in cell-type and species-specific manner, the presented data may serve as the basis in the understanding of mechanisms underlying mutual interactions between AhR and GR. (en)
Title
  • Glucocorticoid Receptor Functions in HeLa Cells Are Perturbed by 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD)
  • Glucocorticoid Receptor Functions in HeLa Cells Are Perturbed by 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD) (en)
  • 2. Funkce glukokortikoidního receptoru v HeLa buňkách jsou narušeny 2,3,8,9-tetrachlorodibenzo-p-dioxinem (TCDD) (cs)
skos:prefLabel
  • Glucocorticoid Receptor Functions in HeLa Cells Are Perturbed by 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD)
  • Glucocorticoid Receptor Functions in HeLa Cells Are Perturbed by 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD) (en)
  • 2. Funkce glukokortikoidního receptoru v HeLa buňkách jsou narušeny 2,3,8,9-tetrachlorodibenzo-p-dioxinem (TCDD) (cs)
skos:notation
  • RIV/61989592:15110/07:00004414!RIV08-MSM-15110___
http://linked.open.../vavai/riv/strany
  • 311-314
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 423481
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/07:00004414
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Receptors; drug-metabolizing enzymes; aryl hydrocarbon; glucocorticoid (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [CA148B12D2FF]
http://linked.open...i/riv/nazevZdroje
  • Drug Metabolism Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 1
http://linked.open...iv/tvurceVysledku
  • Dvořák, Zdeněk
  • Pávek, Petr
  • Ulrichová, Jitka
  • Vrzal, Radim
http://linked.open...n/vavai/riv/zamer
issn
  • 1872-3128
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
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