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| Description
| - Diabetes and its complications, including oxidative stress, are major reasons for medical intervention and one of the most frequent causes of death in developed countries. Several lines of data suggest that the use of certain dietary polyphenolic compounds may alter glucose metabolism, thus decreasing the risk for type 2 diabetes. In this paper, we present the effect of phenolic acids (caffeic, chlorogenic, rosmarinic, and ferulic) and extracts from Smallanthus sonchifolius and Prunella vulgaris on glucose production in rat hepatocytes and on glucokinase, glucose-6-phosphatase, and phosphoenol-pyruvate carboxykinase mRNA expression in rat hepatoma Fao cells. The phenolics at 500 microM and after 1 h incubation lowered glucose production via both gluconeogenesis (10 mM alanine or dihydroxyacetone as precursors) and glycogenolysis compared with metformin. Most of the phenolics increased the level of glucokinase mRNA after 24 h in the same way as insulin (10(-7) M).
- Diabetes and its complications, including oxidative stress, are major reasons for medical intervention and one of the most frequent causes of death in developed countries. Several lines of data suggest that the use of certain dietary polyphenolic compounds may alter glucose metabolism, thus decreasing the risk for type 2 diabetes. In this paper, we present the effect of phenolic acids (caffeic, chlorogenic, rosmarinic, and ferulic) and extracts from Smallanthus sonchifolius and Prunella vulgaris on glucose production in rat hepatocytes and on glucokinase, glucose-6-phosphatase, and phosphoenol-pyruvate carboxykinase mRNA expression in rat hepatoma Fao cells. The phenolics at 500 microM and after 1 h incubation lowered glucose production via both gluconeogenesis (10 mM alanine or dihydroxyacetone as precursors) and glycogenolysis compared with metformin. Most of the phenolics increased the level of glucokinase mRNA after 24 h in the same way as insulin (10(-7) M). (en)
- Diabetes a jeho komplikace, včetně oxidačního stresu, je jednou z hlavních příčin potřeby lékařské intervence a příčin předčasné smrti v rozvinutých zemích. Některá data naznačují, že užívání polyfenolů z potravy může ovlivnit metabolismus glukosy a následně snížit riziko diabetu 2. typu. V této práci popisujeme vliv fenolových kyselin (kávová, chlorogenová, rozmarýnová a ferulová) a extraktů ze Smallanthus sonchifolius a Prunella vulgaris na tvorbu glukosy v potkaních hepatocytech a na expresi mRNA pro glukokinasu, glukosa-6-fosfatasu a fosfoenolpyruvátkarboxykinasu v potkaních hepatomových buňkách Fao. Fenolové látky v koncentracích 500 ?M po jedné hodině inkubace snižovaly produkci glukosy cestou glukoneogenze (10 mM alanin nebo dihydroxyaceton jako prekursory) i glykogenolýzy. Většina látek snižovala po 24 hodinách hladinu mRNA stejným způsobem jako insulin (10-7 M). (cs)
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| Title
| - Induction of glucokinase mRNA by dietary phenolic compounds in rat liver cells in vitro
- Induction of glucokinase mRNA by dietary phenolic compounds in rat liver cells in vitro (en)
- Indukce mRNA glukokinasy fenolovými látkami z potravy v potkaních jaterních buňkách in vitro (cs)
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| skos:prefLabel
| - Induction of glucokinase mRNA by dietary phenolic compounds in rat liver cells in vitro
- Induction of glucokinase mRNA by dietary phenolic compounds in rat liver cells in vitro (en)
- Indukce mRNA glukokinasy fenolovými látkami z potravy v potkaních jaterních buňkách in vitro (cs)
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| skos:notation
| - RIV/61989592:15110/07:00004410!RIV08-MSM-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/07:00004410
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Glucose metabolism; hepatocytes; Fao cells; phenolics; plant extracts (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of Agricultural and Food Chemistry
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Ulrichová, Jitka
- Valentová, Kateřina
- Moncion, Arlette
- Truong, Nhu Trai
- de waziers, Isabelle
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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