| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Vakcinace je jednou z mnoha úspěšných strategií prevence infekčních onemocnění. Z bezpečnostních důvodů moderní vakcinologie opouští používání inaktivovaných nebo atenuovaných mikroorganismů. Antigeny musí být jasně definované, čisté, stabilní a správně prezentované imunitnímu systému hostiteli. Lišící se poměry mezi specifickou CD4+ a CD8+ T buněčnou odpovědí jsou potřebné pro protektivitu individuálních vakcín. Ke stimulaci obou CD4+ a CD8+ T buněk musí být antigeny zpracované a prezentované oběmi antigen-prezentujícími cestami (MHC I a MHC II). Proteinové antigeny doručené vakcinací jsou zpracované jako extracelulární antigeny. Extracelulárně doručený antigen může být nasměrovaný k intracelulární prezentační cestě spojením s molekulami zapojenými ve zkřížené prezentaci (např. heat shock proteiny). Současné znalosti hostitelské imunitní odpovědi k DNA vakcinaci jsou shrnuty v úvodní části. Následující kapitoly diskutují techniky pro zvýšení účinnosti DNA vakcíny, jako je doručení DNA vakcíny ke spec (cs)
- Vaccination is historically one of the most successful strategies for the prevention of infectious diseases. For safety reasons, modern vaccinology tends toward the usage of inactivated or attenuated microorganisms and uses predominantly subunit vaccines. The antigens need to be clearly defined, pure, stable, appropriately composed, and properly presented to the immune system of the host. Differing ratios of various proportions between specific CD4+ and CD8+ T cell responses are essential for conferring the required protection in the case of individual vaccines. To stimulate both CD4+ and CD8+ T cells, the antigens must be processed and presented to both antigen-presentation pathways, MHC I and MHC II. Protein antigens delivered by vaccination are processed as extracellular antigens. However, extracellularly delivered antigen can be directed towards intracellular presentation pathways in conjugation with molecules involved in antigen cross-presentation, e.g. heat shock proteins, or by genomic-DNA vacc
- Vaccination is historically one of the most successful strategies for the prevention of infectious diseases. For safety reasons, modern vaccinology tends toward the usage of inactivated or attenuated microorganisms and uses predominantly subunit vaccines. The antigens need to be clearly defined, pure, stable, appropriately composed, and properly presented to the immune system of the host. Differing ratios of various proportions between specific CD4+ and CD8+ T cell responses are essential for conferring the required protection in the case of individual vaccines. To stimulate both CD4+ and CD8+ T cells, the antigens must be processed and presented to both antigen-presentation pathways, MHC I and MHC II. Protein antigens delivered by vaccination are processed as extracellular antigens. However, extracellularly delivered antigen can be directed towards intracellular presentation pathways in conjugation with molecules involved in antigen cross-presentation, e.g. heat shock proteins, or by genomic-DNA vacc (en)
|
| Title
| - DNA vaccines: are they still just a powerful tool for the future?
- DNA vakcíny jsou stále jen účinným nástrojem budoucnosti? (cs)
- DNA vaccines: are they still just a powerful tool for the future? (en)
|
| skos:prefLabel
| - DNA vaccines: are they still just a powerful tool for the future?
- DNA vakcíny jsou stále jen účinným nástrojem budoucnosti? (cs)
- DNA vaccines: are they still just a powerful tool for the future? (en)
|
| skos:notation
| - RIV/61989592:15110/07:00004339!RIV08-MSM-15110___
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| |
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/07:00004339
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - DNA vaccine; plasmid; delivery systems; CTL; MHC I; MHC II (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - CH - Švýcarská konfederace
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Archivum Immunologiae et Therapiae Experimentalis
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Raška, Milan
- Horynová, Milada
- Weigl, Evžen
- Křupka, Michal
- Běláková, Jana
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
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