| Attributes | Values |
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| rdf:type
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| Description
| - OBJECTIVE: Continuous combined hormone replacement therapy (ccHRT) based on estradiol valerate (E2V) and medroxyprogesterone acetate (MPA) is effective for relief of menopausal symptoms three years or more after the menopause. This study was undertaken to examine the efficacy and tolerability of ccHRT in early postmenopausal women (last menstrual period 1.3 years before study entry). STUDY DESIGN: This was a 52-week, randomized, double-blind, multinational study of ccHRT comprising three different dose combinations of E2V/MPA in 459 early postmenopausal non-hysterectomized women experiencing 30 or more moderate to severe hot flushes a week and/or vasomotor symptoms requiring treatment. MAIN OUTCOMES MEASURES: The primary endpoint was change in frequency and severity of moderate to severe hot flushes at 12 weeks. Secondary outcome measures included number of bleeding days and evaluation of tolerability. RESULTS: The frequency of hot flushes was reduced by >or=70% after one month (P<0.001 for all
- OBJECTIVE: Continuous combined hormone replacement therapy (ccHRT) based on estradiol valerate (E2V) and medroxyprogesterone acetate (MPA) is effective for relief of menopausal symptoms three years or more after the menopause. This study was undertaken to examine the efficacy and tolerability of ccHRT in early postmenopausal women (last menstrual period 1.3 years before study entry). STUDY DESIGN: This was a 52-week, randomized, double-blind, multinational study of ccHRT comprising three different dose combinations of E2V/MPA in 459 early postmenopausal non-hysterectomized women experiencing 30 or more moderate to severe hot flushes a week and/or vasomotor symptoms requiring treatment. MAIN OUTCOMES MEASURES: The primary endpoint was change in frequency and severity of moderate to severe hot flushes at 12 weeks. Secondary outcome measures included number of bleeding days and evaluation of tolerability. RESULTS: The frequency of hot flushes was reduced by >or=70% after one month (P<0.001 for all (en)
- Kontinuální kombinovaná hormonální substituční terapie (HST) s estradiol valerátem a medroxyprogesteron acetátem byla ověřována v 1 rok trvající, randomizované a dvojitě zaslepené mezinárodní klinické studii, do které bylo zahrnuto 459 žen krátce po menopause. Tato HRT byla efektivní pro potlačení klimakterických symptomů a byla dobře tolerována. (cs)
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| Title
| - Efficacy and tolerability of continuous combined hormone replacement therapy in early postmenopausal women
- Účinnost a snášenlivost kontinuální kombinované hormonální substituční terapie u časně postmenopauzálních žen (cs)
- Efficacy and tolerability of continuous combined hormone replacement therapy in early postmenopausal women (en)
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| skos:prefLabel
| - Efficacy and tolerability of continuous combined hormone replacement therapy in early postmenopausal women
- Účinnost a snášenlivost kontinuální kombinované hormonální substituční terapie u časně postmenopauzálních žen (cs)
- Efficacy and tolerability of continuous combined hormone replacement therapy in early postmenopausal women (en)
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| skos:notation
| - RIV/61989592:15110/07:00004163!RIV08-MSM-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/07:00004163
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Continuous combined HRT; hormone replacement therapy; hot flushes; menopause; postmenopausal women (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kudela, Milan
- Mattsson, La.
- Heikkinen, J.
- Mattila, L.
- Mustonen, M.
- Rees, M.
- Salminen, K.
- Skouby, S.
- Stadnicki-Kolendo, A.
- Vuorela, A.
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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