About: Correlation of the IgG index and oligoclonal bands in the CSF of patients with multiple sclerosis     Goto   Sponge   NotDistinct   Permalink

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Description
  • Cíl: Cílem studie bylo vyhodnotit vztah mezi hodnotami indexu IgG a počtem oligoklonálních IgG pásů (OCB) v mozkomíšním moku (CSF) pacientů s roztroušenou sklerózou (SM). Materiál a metodika: Soubor 150 pacientů sestával ze 41 mužů a 109 žen (ve věku od 18 do 68 let, průměrný věk byl 36,6 - 10,1 let). U mozkomíšního moku odebraného lumbální punkcí byla posouzena intratekální syntéza s využitím indexu IgG a stanovením OCB. Počet alkalických OCB v CSF byl stanoven metodou izoelektrické fokusace. K vyhodnocení statistické významnosti výsledků byla rovněž použita Pearsonova korelační analýza, 2 test homogenity, Mannův-Whitneyův test, párový t-test (parametrický) a jednovýběrový Wilcoxonův test (neparametrický). Výsledky: Pozitivní korelace mezi IgG indexem a počtem OCB nebyla nalezena. Ani Mannův-Whitneyův test neprokázal podstatný rozdíl v hodnotách indexu IgG u pacientů s OCB >- 2 a menší než 2. (cs)
  • Objective: The aim of this study was to assess the correlation between IgG index values and the number of the oligoclonal IgG bands (OCB) in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS). Material and Methods: The set of 150 patients consisted of 41 males and 109 females (aged 18?68, mean 36.6 - 10.1 years). The CSF collected by a lumbar puncture was examined evaluating intrathecal synthesis using the IgG index and determining OCB. The number of alkaline OCB in the CSF was assessed using the method of isoelectric focusation. Pearson's correlation analysis, and homogeneity 2 test , Mann-Whitney test, paired-sample t-test (parametric) and Wilcoxon signed-ranks test (nonparametric) were used to evaluate the statistical significance of the results. Results: No positive correlation between the IgG index and the number of OCB was found. Mann-Whitney test also did not demonstrate any significant difference of the IgG index values in patients both with the OCB number
  • Objective: The aim of this study was to assess the correlation between IgG index values and the number of the oligoclonal IgG bands (OCB) in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS). Material and Methods: The set of 150 patients consisted of 41 males and 109 females (aged 18?68, mean 36.6 - 10.1 years). The CSF collected by a lumbar puncture was examined evaluating intrathecal synthesis using the IgG index and determining OCB. The number of alkaline OCB in the CSF was assessed using the method of isoelectric focusation. Pearson's correlation analysis, and homogeneity 2 test , Mann-Whitney test, paired-sample t-test (parametric) and Wilcoxon signed-ranks test (nonparametric) were used to evaluate the statistical significance of the results. Results: No positive correlation between the IgG index and the number of OCB was found. Mann-Whitney test also did not demonstrate any significant difference of the IgG index values in patients both with the OCB number (en)
Title
  • Correlation of the IgG index and oligoclonal bands in the CSF of patients with multiple sclerosis
  • Korelace mezi indexem IgG a oligoklonálními pásy při CSF vyšetření u pacientů s roztroušenou sklerózou (cs)
  • Correlation of the IgG index and oligoclonal bands in the CSF of patients with multiple sclerosis (en)
skos:prefLabel
  • Correlation of the IgG index and oligoclonal bands in the CSF of patients with multiple sclerosis
  • Korelace mezi indexem IgG a oligoklonálními pásy při CSF vyšetření u pacientů s roztroušenou sklerózou (cs)
  • Correlation of the IgG index and oligoclonal bands in the CSF of patients with multiple sclerosis (en)
skos:notation
  • RIV/61989592:15110/07:00004155!RIV08-MSM-15110___
http://linked.open.../vavai/riv/strany
  • 392-394
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 415146
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/07:00004155
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • oligoclonal bands; cerebrospinal fluid; IgG index; multiple sclerosis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [8A3B7B9FBA0F]
http://linked.open...i/riv/nazevZdroje
  • Česká a slovenská neurologie a neurochirurgie
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 70
http://linked.open...iv/tvurceVysledku
  • Mareš, Jan
  • Urbánek, Karel
  • Zapletalová, Jana
  • Herzig, Roman
  • Kaňovský, Petr
  • Schneiderka, Petr
  • Hluštík, Petr
  • Sládková, Vladimíra
  • Opavský, Robert
  • Kollárová, Katarína
  • Bekárek, Vojtěch
  • Podivínský, Jiří
  • Sklenářová, Jarmila
issn
  • 1210-7859
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
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