About: Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Předmětem studie bylo hodnotit rozdíly ve fototoxicitě bergamotových olejů od čtyř různých dodavatelů. Byly provedeny spektrální a chemické analýzy pro identifikaci přítomnosti fotoaktivních složek ve vzorcích. Fototoxicita byla stanovena in vitro 3T3NRU testem a na 3D kožním modelu. Studie prokázala výkonost strategie postupného testování, ale extrapolace výsledků in vitro vzhledem k humánní situaci v praxi může být zatím provedena v omezeném rozsahu. (cs) The aim of this study was to clarify the differences in the phototoxicity of bergamot oil obtained from four different suppliers. Spectral and chemical analyses were perfomed to identify presence of photoactive compounds in the test samples. The phototoxicity was assessed in vitro by the 3T3 NRU phototoxicity test (PT) and subsequently in a phototoxicity test on reconstructed human skin model (H3D PT). Confirmatory photopatch tests in a group of volunteers were performed using the first non-phototoxic concentration determined in the H3DPT. Although the study showed the usefulness of the tiered testing strategy, currently, the extrapolation of in vitro results to human situation may performed only to a limited extent. The aim of this study was to clarify the differences in the phototoxicity of bergamot oil obtained from four different suppliers. Spectral and chemical analyses were perfomed to identify presence of photoactive compounds in the test samples. The phototoxicity was assessed in vitro by the 3T3 NRU phototoxicity test (PT) and subsequently in a phototoxicity test on reconstructed human skin model (H3D PT). Confirmatory photopatch tests in a group of volunteers were performed using the first non-phototoxic concentration determined in the H3DPT. Although the study showed the usefulness of the tiered testing strategy, currently, the extrapolation of in vitro results to human situation may performed only to a limited extent. (en)
Title	Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests Fototoxicita bergamotových olejů hodnocena in vitro technikami v kombinaci s kožními testy na lidských dobrovolnících (cs) Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests (en)
skos:prefLabel	Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests Fototoxicita bergamotových olejů hodnocena in vitro technikami v kombinaci s kožními testy na lidských dobrovolnících (cs) Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests (en)
skos:notation	RIV/61989592:15110/07:00004141!RIV08-MSM-15110___
http://linked.open.../vavai/riv/strany	1298-1303
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Kolářová, Hana Bendová, Hana Kejlová, Kristýna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	441279
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/07:00004141
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Phototoxicity; Bergamot oils; 3T3 NRU phototoxicity test; 3D human skin model; Photopatch test (en)
http://linked.open.../riv/klicoveSlovo	Phototoxicity 3D human skin model 3T3 NRU phototoxicity test Bergamot oils Photopatch test
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E13F13A8946D]
http://linked.open...i/riv/nazevZdroje	Toxicology in Vitro
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Bendová, Hana Kolářová, Hana Jírová, Dagmar Kejlová, Kristina Kandárová, H. Liebsch, M. Weidenhoffer, Z.
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0887-2333
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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