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Description
| - Předmětem studie bylo hodnotit rozdíly ve fototoxicitě bergamotových olejů od čtyř různých dodavatelů. Byly provedeny spektrální a chemické analýzy pro identifikaci přítomnosti fotoaktivních složek ve vzorcích. Fototoxicita byla stanovena in vitro 3T3NRU testem a na 3D kožním modelu. Studie prokázala výkonost strategie postupného testování, ale extrapolace výsledků in vitro vzhledem k humánní situaci v praxi může být zatím provedena v omezeném rozsahu. (cs)
- The aim of this study was to clarify the differences in the phototoxicity of bergamot oil obtained from four different suppliers. Spectral and chemical analyses were perfomed to identify presence of photoactive compounds in the test samples. The phototoxicity was assessed in vitro by the 3T3 NRU phototoxicity test (PT) and subsequently in a phototoxicity test on reconstructed human skin model (H3D PT). Confirmatory photopatch tests in a group of volunteers were performed using the first non-phototoxic concentration determined in the H3DPT. Although the study showed the usefulness of the tiered testing strategy, currently, the extrapolation of in vitro results to human situation may performed only to a limited extent.
- The aim of this study was to clarify the differences in the phototoxicity of bergamot oil obtained from four different suppliers. Spectral and chemical analyses were perfomed to identify presence of photoactive compounds in the test samples. The phototoxicity was assessed in vitro by the 3T3 NRU phototoxicity test (PT) and subsequently in a phototoxicity test on reconstructed human skin model (H3D PT). Confirmatory photopatch tests in a group of volunteers were performed using the first non-phototoxic concentration determined in the H3DPT. Although the study showed the usefulness of the tiered testing strategy, currently, the extrapolation of in vitro results to human situation may performed only to a limited extent. (en)
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Title
| - Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests
- Fototoxicita bergamotových olejů hodnocena in vitro technikami v kombinaci s kožními testy na lidských dobrovolnících (cs)
- Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests (en)
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skos:prefLabel
| - Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests
- Fototoxicita bergamotových olejů hodnocena in vitro technikami v kombinaci s kožními testy na lidských dobrovolnících (cs)
- Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests (en)
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skos:notation
| - RIV/61989592:15110/07:00004141!RIV08-MSM-15110___
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/07:00004141
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Phototoxicity; Bergamot oils; 3T3 NRU phototoxicity test; 3D human skin model; Photopatch test (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Bendová, Hana
- Kolářová, Hana
- Jírová, Dagmar
- Kejlová, Kristina
- Kandárová, H.
- Liebsch, M.
- Weidenhoffer, Z.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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