Description
| - The aim of our study was to evaluate the relationship of adiponectin to soluble forms of vascular cell adhesion molecule-l (sVCAM-1) and intercellular cell adhesion molecule-1 (sICAM-1) in patients with cardiovascular disease or dyslipidemia. Two hundred and sixty-four patients (134 men/130 women, mean age 43,8?14,8/46,0?14,9 years) of Lipid Center, University Hospital Olomouc, off hypolipidemic therapy for at least 6 weeks, participated in the study. In multiple regression analysis, adiponectin was independently positively associated with serum HDL-cholesterol (p<0,0001) and sVCAM-1 (p<0,0001), female gender (p<0,0001) and negatively with hs-CRP (p=0,014). Serum concentration of adiponectin and sICAM-1 did not correlate but sICAM-1 was independently, positively associated with sVCAM-1 (p<0,0001) and negatively with markers of insulin resistance and inflammation, namely atherogenic index log(triglycerides/HDL-cholesterol) (p<0,0001), hs-CRP (p<0,001) and HOMA (p<0,05). Positive
- The aim of our study was to evaluate the relationship of adiponectin to soluble forms of vascular cell adhesion molecule-l (sVCAM-1) and intercellular cell adhesion molecule-1 (sICAM-1) in patients with cardiovascular disease or dyslipidemia. Two hundred and sixty-four patients (134 men/130 women, mean age 43,8?14,8/46,0?14,9 years) of Lipid Center, University Hospital Olomouc, off hypolipidemic therapy for at least 6 weeks, participated in the study. In multiple regression analysis, adiponectin was independently positively associated with serum HDL-cholesterol (p<0,0001) and sVCAM-1 (p<0,0001), female gender (p<0,0001) and negatively with hs-CRP (p=0,014). Serum concentration of adiponectin and sICAM-1 did not correlate but sICAM-1 was independently, positively associated with sVCAM-1 (p<0,0001) and negatively with markers of insulin resistance and inflammation, namely atherogenic index log(triglycerides/HDL-cholesterol) (p<0,0001), hs-CRP (p<0,001) and HOMA (p<0,05). Positive (en)
- Cílem naší práce bylo zhodnotit vztah adiponektinu k solubilním formám adhezivních molekul sVCAM-1 a sICAM-1 u pacientů s přítomností kardiovaskulárního onemocnění nebo s dyslipidémií. Studie se zúčastnilo 264 pacientů (134 mužů/130 žen, průměrný věk 43,8?14,8 let) lipidové poradny Fakultní nemocnice Olomouc, kteří nebyli v posledních 6 týdnech léčeni hypolipidemickou léčbou. V mnohonásobné regresní analýze byl adiponektin nezávisle pozitivně asociován s hladinami HDL-cholesterolu (p<0,0001) a sVCAM-1 (p<0,0001), s ženským pohlavím (p<0,0001) a negativně s hs-CRP (p=0,014). Sérové koncentrace sICAM-1 nekorelovaly s hladinami adiponektinu, ale korelovaly pozitivně se sVCAM-1 (p<0,0001) a negativně s markery inzulínové rezistence a zánětu, zejména s aterogenním indexem log(triglyceridy/HDL-cholesterol) (p<0,0001), hs-CRP (p<0,001) a HOMA (p<0,05). Pozitivní asociace adiponektinu s HDL-cholesterolem a negativní asociace s hs-CRP ukazuje na antiaterogenní vlastnosti adiponektinu. (cs)
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