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  • For almost forty years now, platinum complexes are known to possess the antineoplastic activity1. The most prominent antineoplastic drug of this class is the cisplatin (cis-diamminedichloroplatinum (II)) used to treat many types of cancer either in monotherapy or in combination with other drugs or with radiotherapy. The proper positioning of the ligands of the complex appeared to be crucial for the therapeutic eff ect of this drug as the trans complex of the same chemical composition having the identical ligands of platinum (i.e. two amino groups or two chlorides at the opposite side of the square-like planar platinum complex) does not exhibit the desired antitumor activity. Although the platinumbased chemotherapeutic drugs are in use for long time, little is known about their interactions with liver microsomal cytochrome P450 enzymes which are known to play a crucial role in metabolism of the majority of drugs and other xenobiotics. There is in the literature only one study performe
  • For almost forty years now, platinum complexes are known to possess the antineoplastic activity1. The most prominent antineoplastic drug of this class is the cisplatin (cis-diamminedichloroplatinum (II)) used to treat many types of cancer either in monotherapy or in combination with other drugs or with radiotherapy. The proper positioning of the ligands of the complex appeared to be crucial for the therapeutic eff ect of this drug as the trans complex of the same chemical composition having the identical ligands of platinum (i.e. two amino groups or two chlorides at the opposite side of the square-like planar platinum complex) does not exhibit the desired antitumor activity. Although the platinumbased chemotherapeutic drugs are in use for long time, little is known about their interactions with liver microsomal cytochrome P450 enzymes which are known to play a crucial role in metabolism of the majority of drugs and other xenobiotics. There is in the literature only one study performe (en)
  • Tato práce prezentuje výsledky pilotní studie zabývající se inhibicí různých isoforem cytochromů P450 v lidské mikrosomální frakci působením %22klasických%22 chemoterapeutik (cisplatina, transplatina) na bázi platinových komplexů. (cs)
Title
  • ON THE POSSIBLE INTERACTION OF PLATINUM CHEMOTHERAPEUTICS
  • Možné interakce platinových chemoterapeutik (cs)
  • ON THE POSSIBLE INTERACTION OF PLATINUM CHEMOTHERAPEUTICS (en)
skos:prefLabel
  • ON THE POSSIBLE INTERACTION OF PLATINUM CHEMOTHERAPEUTICS
  • Možné interakce platinových chemoterapeutik (cs)
  • ON THE POSSIBLE INTERACTION OF PLATINUM CHEMOTHERAPEUTICS (en)
skos:notation
  • RIV/61989592:15110/07:00003644!RIV08-AV0-15110___
http://linked.open.../vavai/riv/strany
  • 51-52
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(KAN200200651)
http://linked.open...iv/cisloPeriodika
  • S1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 439414
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/07:00003644
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Cisplatin; Transplatin; Cytochrome P450; CYP (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [6B9ED5557137]
http://linked.open...i/riv/nazevZdroje
  • Biomedical Papers
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 151
http://linked.open...iv/tvurceVysledku
  • Brabec, V.
  • Anzenbacher, Pavel
  • Anzenbacherová, Eva
  • Mašek, Vlastimil
  • Machová, M.
issn
  • 1213-8118
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
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