About: Analysis of ERBB2 and TOP2A gene status using fluorescence in situ hybridization versus immunohistochemistry in localized breast cancer.

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About: Analysis of ERBB2 and TOP2A gene status using fluorescence in situ hybridization versus immunohistochemistry in localized breast cancer. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of our study was to assess the ERBB2 and TOP2A gene status in breast carcinoma tissue using fluorescence in situ hybridization (FISH) and to compare their amplification with immunohistochemistry assay (IHC) of the ERBB2, resp. topoisomerase IIα proteins. TOP2A status is important in tailored treatment as topoisomerase IIα is the molecular target afor topoisomerase IIα inhibitors. This study was conducted to determine whether the methods are equivalent in their assessment of TOP2A status and to correlate the genetic findings with basic tumor and disease characteristics. The aim of our study was to assess the ERBB2 and TOP2A gene status in breast carcinoma tissue using fluorescence in situ hybridization (FISH) and to compare their amplification with immunohistochemistry assay (IHC) of the ERBB2, resp. topoisomerase IIα proteins. TOP2A status is important in tailored treatment as topoisomerase IIα is the molecular target afor topoisomerase IIα inhibitors. This study was conducted to determine whether the methods are equivalent in their assessment of TOP2A status and to correlate the genetic findings with basic tumor and disease characteristics. (en) Cílem práce bylo stanovit korelaci mezi vyšetřením statusu genu Her-2/neu a TOP2A metodou fluorescenční in situ hybridizace (FISH) a imnuohistochemicky (IHC). Smyslem bylo získat infiormace o zastupitelnosti obou metod pro účely klinické praxe. (cs)
Title	Analysis of ERBB2 and TOP2A gene status using fluorescence in situ hybridization versus immunohistochemistry in localized breast cancer. Analýza statusu genu HER 2/neu a TO 2A porovnání metod FISH a IHC u karcinomu prsu. (cs) Analysis of ERBB2 and TOP2A gene status using fluorescence in situ hybridization versus immunohistochemistry in localized breast cancer. (en)
skos:prefLabel	Analysis of ERBB2 and TOP2A gene status using fluorescence in situ hybridization versus immunohistochemistry in localized breast cancer. Analýza statusu genu HER 2/neu a TO 2A porovnání metod FISH a IHC u karcinomu prsu. (cs) Analysis of ERBB2 and TOP2A gene status using fluorescence in situ hybridization versus immunohistochemistry in localized breast cancer. (en)
skos:notation	RIV/61989592:15110/07:00002700!RIV07-MPO-15110___
http://linked.open.../vavai/riv/strany	393-401
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1H-PK/45), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Hajdúch, Marián Mihál, Vladimír KOLÁŘ, Zdeněk BOUCHALOVÁ, Kateřina Trojanec, Radek Cwiertka, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	409464
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/07:00002700
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ERBB2; topoisomerase II; breast carcinoma; FISH; immunohistochemistry; anthracycline (en)
http://linked.open.../riv/klicoveSlovo	FISH immunohistochemistry anthracycline breast carcinoma ERBB2 topoisomerase II
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[5B09B03F8C8F]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Current biotechnologies for research and development of diagnostic tools for prediction of therapy response in breast cancer patients.
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	53
http://linked.open...iv/tvurceVysledku	Hajdúch, Marián Mihál, Vladimír Kolář, Zdeněk Trojanec, Radek Bouchalová, Kateřina Černáková, Iveta Ćwiertka, Karel
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0028-2685
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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