| Attributes | Values |
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| rdf:type
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| Description
| - Estradiol/progesteronová substituce vyvolává dramatické změny v expresi estrogen senzitivních genů MMP-26 a TIMP-4, které mohou nepříznivě ovlivnit výsledek IVF. (cs)
- BACKGROUND: The aim of this study was to analyse the effects of an estradiol (E2)?progesterone substitution protocol on the endometrial expression of estrogen-sensitive genes during the peri-implantation period. METHODS: Peripheral blood and endometrial biopsies were obtained from 13 infertile women both in a natural cycle (NC), on days 5 and 7 after ovulation (NC5, NC7), and in an artificial (substituted) cycle (AC), on days 5 and 7 of progesterone addition (AC5, AC7). Estrogen receptor-α (ER α) and progesterone receptor (PR) were assayed by immunohistochemistry. Matrix metalloproteinase-26 (MMP-26) mRNA and tissue inhibitor of metalloproteinase-4 (TIMP-4) mRNA were semiquantitatively assessed in tissue sections using in situ hybridization (ISH) and quantified in tissue extracts using real-time PCR. RESULTS: Levels of both E2 and progesterone were higher in the peripheral blood in AC than in NC. Also on day AC5, expressions of ER α, PR and MMP-26 mRNA (focally) were increased in the e
- BACKGROUND: The aim of this study was to analyse the effects of an estradiol (E2)?progesterone substitution protocol on the endometrial expression of estrogen-sensitive genes during the peri-implantation period. METHODS: Peripheral blood and endometrial biopsies were obtained from 13 infertile women both in a natural cycle (NC), on days 5 and 7 after ovulation (NC5, NC7), and in an artificial (substituted) cycle (AC), on days 5 and 7 of progesterone addition (AC5, AC7). Estrogen receptor-α (ER α) and progesterone receptor (PR) were assayed by immunohistochemistry. Matrix metalloproteinase-26 (MMP-26) mRNA and tissue inhibitor of metalloproteinase-4 (TIMP-4) mRNA were semiquantitatively assessed in tissue sections using in situ hybridization (ISH) and quantified in tissue extracts using real-time PCR. RESULTS: Levels of both E2 and progesterone were higher in the peripheral blood in AC than in NC. Also on day AC5, expressions of ER α, PR and MMP-26 mRNA (focally) were increased in the e (en)
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| Title
| - Endometrial expression of the estrogen-sensitive genes MMP-26 and TIMP-4 is altered by a substitution protocol without down-regulation in IVF patiens
- Endometrální exprese estrogen senzitivních genů MMP-26 a TIMP-4 je změněna substitučním protokolem bez downregulace u IVF pacientek (cs)
- Endometrial expression of the estrogen-sensitive genes MMP-26 and TIMP-4 is altered by a substitution protocol without down-regulation in IVF patiens (en)
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| skos:prefLabel
| - Endometrial expression of the estrogen-sensitive genes MMP-26 and TIMP-4 is altered by a substitution protocol without down-regulation in IVF patiens
- Endometrální exprese estrogen senzitivních genů MMP-26 a TIMP-4 je změněna substitučním protokolem bez downregulace u IVF pacientek (cs)
- Endometrial expression of the estrogen-sensitive genes MMP-26 and TIMP-4 is altered by a substitution protocol without down-regulation in IVF patiens (en)
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| skos:notation
| - RIV/61989592:15110/06:00003923!RIV08-MZ0-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/06:00003923
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - estrogen; implantation; mRNA; progesterone receptor; regulation (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Human Reproduction Update
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Fingerová, Helena
- Oborná, Ivana
- Havelka, Pavel
- Pilka, Radovan
- Hansson, Stefan
- Lichnovský, Václav
- Casslen, Bertil
- Eriksson, Per
|
| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
| |
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