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| Description
| - The majority of translocations that involve the long arms of chromosomes 11 and 17 in acute myeloid leukemia appear identical on the cytogenetic level. nevertheless, they are diverse on the molecular level. At present, two genes are known in 11q23 and four in 17q12-25 that generate five distinct fusion genes: MLL-MLLT6/AF17, MLL- LASP1, MLL-ACACA or MLL-SEPT9/MSF, and ZBTB16/PLZF-RARA. We analyzed 14 cases with a t (11;17) by fluorescence in situ hybridization and molecular genetic techniques and determined the molecular characteristics of their fusion genes. We identified six different gene fusions that comprised seven cases eith a MLL-MLLT6/AF17, three with a MLL-SEPT9/MSF and one each with MLL-LASP1, MLL-ACACA and ZBTB16/PLZF-RARA fusions. In the remaining case, a MLL-SEPT6/Xq24 fusion suggested a complex rearrangement. The MLL-MLL6/AF17 transcripts were extremely heterogeneous and the detection of seven different in-frame transcript and splice variants enabled us to predict the protein domain rele
- The majority of translocations that involve the long arms of chromosomes 11 and 17 in acute myeloid leukemia appear identical on the cytogenetic level. nevertheless, they are diverse on the molecular level. At present, two genes are known in 11q23 and four in 17q12-25 that generate five distinct fusion genes: MLL-MLLT6/AF17, MLL- LASP1, MLL-ACACA or MLL-SEPT9/MSF, and ZBTB16/PLZF-RARA. We analyzed 14 cases with a t (11;17) by fluorescence in situ hybridization and molecular genetic techniques and determined the molecular characteristics of their fusion genes. We identified six different gene fusions that comprised seven cases eith a MLL-MLLT6/AF17, three with a MLL-SEPT9/MSF and one each with MLL-LASP1, MLL-ACACA and ZBTB16/PLZF-RARA fusions. In the remaining case, a MLL-SEPT6/Xq24 fusion suggested a complex rearrangement. The MLL-MLL6/AF17 transcripts were extremely heterogeneous and the detection of seven different in-frame transcript and splice variants enabled us to predict the protein domain rele (en)
- Většina translokací postihujících u nemocných s akutní myeloidní leukemií dlouhá raménka chromosomů 11 a 17 má při cytogenetickém vyšetření identický obraz. Na molekulární úrovni jde o různé fúzní geny. V práci jsou popisovány molekulární charakteristiky leukemických fúzí u 14 případů AML s t(11;17). (cs)
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| Title
| - Molecular dissection of t)11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants
- Molekulární analýza translokace t(11;17) u akutní myeloidní leukemie odhaluje přítomnost různých genových fúzí s heterogenní transkripcí a četnými variantami (cs)
- Molecular dissection of t)11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants (en)
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| skos:prefLabel
| - Molecular dissection of t)11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants
- Molekulární analýza translokace t(11;17) u akutní myeloidní leukemie odhaluje přítomnost různých genových fúzí s heterogenní transkripcí a četnými variantami (cs)
- Molecular dissection of t)11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants (en)
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| skos:notation
| - RIV/61989592:15110/06:00003510!RIV07-MSM-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/06:00003510
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - acute monocytic leukemia; acute myelomonocytic leukemia; acute promyelocytic leukemia; acute myeloblastic-leukemia; acute myelocytic-leukemi; septin ffamily gene; adult de-novo; MLL gene; leucine-zipper, retinoic acid (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Genes, Chromosomes and Cancer
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Jarošová, Marie
- Jäger, U.
- Meyer, C.
- Schmidt, H.
- Harbott, J.
- Strehl, S.
- Schneider, B.
- Haas, O.
- Moore, S.
- Marschalek, Rolf
- Konig, M.
- Von bergh, A.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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