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| Description
| - Cíle: Tento souborný článek shrnuje studie věnující se zapojení sanguinarinu a chelerythrinu do regulace buněčného cyklu a vlivu na buněčnou smrt u různých buněčných linií. Článek je zaměřen na možné využití těchto látek při léčbě rakoviny. Metody: Vyhledali jsme práce v databázích PubMed, ScienceDirect a Medline zaměřené na molekulární mechanismus biologické aktivity sanguinarinu a chelerythrinu, které byly publikovány v letech 1995 - 2006. Výsledky a závěry: Výsledky z použitých publikací naznačují, že tyto alkaloidy nejsou pouze vhodnými kandidáty pro chemoterapeutické využití, ale rovněž mohou přispět k vývoji vhodné imunní léčby některých typů rakovin díky jejich apoptotické schopnosti. Nicméně úplná signální dráha, kterou sanguinarin a chelerythrin indukuje apoptotickou buněčnou smrt není dosud objasněna. Z výsledků nedávných studií lze soudit, že sanguinarin a chelerythrin se může uplatnit jako látka při léčbě rakoviny. (cs)
- OBJECTIVES: This review summarizes the involvement of sanguinarine and chelerythrine in cell cycle regulation and cell death in various cell lines. It is focused on their potential in the treatment of cancer. METHODS: We conducted a search of PubMed, ScienceDirect and Medline for papers on the molecular mechanisms of the biological activity of sanguinarine and chelerythrine published mainly from 1995 to 2006. RESULTS AND CONCLUSIONS: Our analysis of the published studies suggested that these alkaloids are not only good candidates for chemotherapeutic regimens but may also contribute to the development of successful immune therapies of some carcinomas due to their apoptotic potential. However, the complete signalling cascade in which sanguinarine and chelerythrine treatment induces apoptotic cell death is not yet understood. Overall, the results of recent studies suggest that sanguinarine and chelerythrine may be useful as agents in the management of cancer.
- OBJECTIVES: This review summarizes the involvement of sanguinarine and chelerythrine in cell cycle regulation and cell death in various cell lines. It is focused on their potential in the treatment of cancer. METHODS: We conducted a search of PubMed, ScienceDirect and Medline for papers on the molecular mechanisms of the biological activity of sanguinarine and chelerythrine published mainly from 1995 to 2006. RESULTS AND CONCLUSIONS: Our analysis of the published studies suggested that these alkaloids are not only good candidates for chemotherapeutic regimens but may also contribute to the development of successful immune therapies of some carcinomas due to their apoptotic potential. However, the complete signalling cascade in which sanguinarine and chelerythrine treatment induces apoptotic cell death is not yet understood. Overall, the results of recent studies suggest that sanguinarine and chelerythrine may be useful as agents in the management of cancer. (en)
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| Title
| - Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis
- Vliv sanguinarinu a chelerythrinu na buněčný cyklus a apoptózu. (cs)
- Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis (en)
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| skos:prefLabel
| - Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis
- Vliv sanguinarinu a chelerythrinu na buněčný cyklus a apoptózu. (cs)
- Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis (en)
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| skos:notation
| - RIV/61989592:15110/06:00003482!RIV07-MSM-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/06:00003482
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Quaternary benzo[c]phenanthridine alkaloids; Cytotoxicity; Apoptosis; Cancer; Cell signalling; Proliferation (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Malíková, Jana
- Hlobilková, Alice
- Zdařilová, Adéla
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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