| Attributes | Values |
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| rdf:type
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| Description
| - Dospělým potkanům byl orálně aplikována sanguinarin (10 mg/kg tělesné hmotnosti) v 1.0 ml vody. Dihydrosanguinarin byl identifikován pomocí kapalinové chromatografie- hmotnostní spektrometrie jako metabolit sanguinarinu v plazmě a játrech, jeho hladina byla vyšší než hladina sanguinarinu. Dihydrosanguinarin ani sanguinarin nebyly nalezeny v moči. Tvorba dihydrosanguinarinu je pravděpodobmě prvním krokem detoxifikace sanguinarinu. Benz[c]akridin, v literatuře uváděný metabolit sanguinarinu, nebyl nalezen v moči, plazmě ani v játrech. (cs)
- Adult rats were orally administered with a single dose of sanguinarine (10 mg SA per 1 kg body weight) in 1.0 ml water. In the plasma and the liver, dihydrosanguinarine (DHSA) was identified as a SA metabolite by high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC/ESI-MS). Significantly higher levels of DHSA were found in both the plasma and the liver in comparison with those of SA. SA and DHSA were not detected in the urine. The formation of DHSA might be the first step of SA detoxification in the organism and its subsequent elimination in phase II reactions. Benz[c]acridine (BCA), in the literature cited SA metabolite, was found neither in urine nor in plasma and liver.
- Adult rats were orally administered with a single dose of sanguinarine (10 mg SA per 1 kg body weight) in 1.0 ml water. In the plasma and the liver, dihydrosanguinarine (DHSA) was identified as a SA metabolite by high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC/ESI-MS). Significantly higher levels of DHSA were found in both the plasma and the liver in comparison with those of SA. SA and DHSA were not detected in the urine. The formation of DHSA might be the first step of SA detoxification in the organism and its subsequent elimination in phase II reactions. Benz[c]acridine (BCA), in the literature cited SA metabolite, was found neither in urine nor in plasma and liver. (en)
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| Title
| - A liquid chromatographic-mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat
- A liquid chromatographic-mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat (en)
- Důkaz dihydrosanguinarinu jako prvního metabolitu transformace sanguinarinu u potkana pomocí kapalinové chromatografie-hmotnostní spektrometrie (cs)
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| skos:prefLabel
| - A liquid chromatographic-mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat
- A liquid chromatographic-mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat (en)
- Důkaz dihydrosanguinarinu jako prvního metabolitu transformace sanguinarinu u potkana pomocí kapalinové chromatografie-hmotnostní spektrometrie (cs)
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| skos:notation
| - RIV/61989592:15110/06:00003477!RIV07-MSM-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/06:00003477
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Quaternary benzo[c]phenanthridine alkaloid; Sanguinarine; Rat; Metabolite; Liquid chromatography-mass spectrometry; Liver; Plasma; Dihydrosanguinarine; Benz[c]acridine (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kosina, Pavel
- Kubáň, Vlastimil
- Ulrichová, Jitka
- Klejdus, Bořivoj
- Šimánek, Vilím
- Večeřa, Rostislav
- Vičar, Jaroslav
- Psotová, Jitka
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
| |
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