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| Description
| - Antioxidanty zlepšují proces reparace a hojení kožní tkáně. Aplikace silymarinu, extraktu ze Silybum marianum, potlačuje chemicky vyvolaný oxidační stres u myší. V této studii jsme sledovaly protektivní účinek silymarinu, jeho flavonolignanů, silybinu a dehydrosilybinu, a flavonoidů, kvercetinu a taxifolinu, na lidských keratinocytech a myších fibroblastech poškozených peroxidem vodíku. Cytotoxicita peroxidu vodíku byla koncentračně závislá na obou buněčných linií. Aplikace testovaných látek na buňky před intoxikací H2O2 vedla k poklesu oxidačního poškození. Nejúčinnější byl dehydrosilybin a kvercetin. Vliv silymarinu byl srovnatelný se silybinem, který je jeho hlavní obsahovou složkou. Protektivní účinek koreluje s antioxidační aktivitou látek. Naše výsledky naznačují, že podání silymarinu, flavonolignanů a flavonoidů může zlepšit proces regenerace kůže. (cs)
- The administration of antioxidants has been shown to enhance repair and healing processes in cutaneous tissue. Silymarin, an extract from Silybum marianum has been reported to be beneficial in the treatment of chemically-induced oxidative stress in mouse. In this study, we investigated the protective effects of silymarin, its flavonolignans silybin and dehydrosilybin and flavonoids quercetin and taxifolin against hydrogen peroxide-induced damage to human keratinocytes and mouse fibroblasts. The results showed that the cytotoxicity of hydrogen peroxide was dose-dependent in both cell lines. Pre-treatment with test compounds decreased oxidative injury. Dehydrosilybin and quercetin were the most powerful protectants. Silymarin was comparable to silybinin, its main component. This correlates with the antioxidant potential of the compounds. Our findings suggest that silymarin, flavonolignans and flavonoids may be useful as agents for improving skin tissue regeneration.
- The administration of antioxidants has been shown to enhance repair and healing processes in cutaneous tissue. Silymarin, an extract from Silybum marianum has been reported to be beneficial in the treatment of chemically-induced oxidative stress in mouse. In this study, we investigated the protective effects of silymarin, its flavonolignans silybin and dehydrosilybin and flavonoids quercetin and taxifolin against hydrogen peroxide-induced damage to human keratinocytes and mouse fibroblasts. The results showed that the cytotoxicity of hydrogen peroxide was dose-dependent in both cell lines. Pre-treatment with test compounds decreased oxidative injury. Dehydrosilybin and quercetin were the most powerful protectants. Silymarin was comparable to silybinin, its main component. This correlates with the antioxidant potential of the compounds. Our findings suggest that silymarin, flavonolignans and flavonoids may be useful as agents for improving skin tissue regeneration. (en)
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| Title
| - Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts
- Vliv silymarinu a jeho flavonolignanů na oxidační stres vyvolaný peroxidem vodíku v lidských keratinocytech a myších fibroblastech (cs)
- Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts (en)
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| skos:prefLabel
| - Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts
- Vliv silymarinu a jeho flavonolignanů na oxidační stres vyvolaný peroxidem vodíku v lidských keratinocytech a myších fibroblastech (cs)
- Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts (en)
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| skos:notation
| - RIV/61989592:15110/06:00003474!RIV07-MSM-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/06:00003474
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Silymarin; Flavonolignans; Flavonoids; Oxidative stress; Hydrogen peroxide; Keratinocytes; Fibroblasts; Cytoprotection (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Svobodová, Alena
- Walterová, Daniela
- Psotová, Jitka
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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