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| Description
| - A novel HLA-B (human leukocyte antigen-B) allele, HLAB*4442, was identified both in a Czech patient with leukaemia and in his mother. The presence of a novel allele was initially suspected because conflicting results were obtained by serological and DNA typing techniques. The HLA typing using the polymerase chain reaction-sequence-specific primers (PCR-SSP) at the two-digit level indicated an allele belonging to the HLA-B*44 group, whereas serological typing indicated HLA-B21. Typing with PCR-sequence-specific oligonucleotides (PCR-SSO) resulted in a unique reaction pattern that could not be assigned to a known allele, PCR-SSP typing at the four-digit level did not match any known B*44 allele, either. The sequencing-based typing of the HLA-B locus then revealed the novel B*4442 allele that is identical with B*4405 except a single C→G nucleotide exchange at position 572. This exchange results in an amino acid substitution from serine to tryptophan at position 167 of the expressed HLA-B protei
- A novel HLA-B (human leukocyte antigen-B) allele, HLAB*4442, was identified both in a Czech patient with leukaemia and in his mother. The presence of a novel allele was initially suspected because conflicting results were obtained by serological and DNA typing techniques. The HLA typing using the polymerase chain reaction-sequence-specific primers (PCR-SSP) at the two-digit level indicated an allele belonging to the HLA-B*44 group, whereas serological typing indicated HLA-B21. Typing with PCR-sequence-specific oligonucleotides (PCR-SSO) resulted in a unique reaction pattern that could not be assigned to a known allele, PCR-SSP typing at the four-digit level did not match any known B*44 allele, either. The sequencing-based typing of the HLA-B locus then revealed the novel B*4442 allele that is identical with B*4405 except a single C→G nucleotide exchange at position 572. This exchange results in an amino acid substitution from serine to tryptophan at position 167 of the expressed HLA-B protei (en)
- Nová HLA-B alela, HLAB*4442, byla identifikována u českého pacienta s leukémií a jeho matky. Přítomnost této nové alely byla předpokládána, protože serologické výsledky neodpovídaly DNA typizačním technikám. HLA typizace používající PCR-SSP (polymerase chain reaction-sequence-specific primers) naznačila alelu HLA-B*44 skupiny, zatímco serologická typizace ukazovala na HLA-B21. PCR-SSO (PCR-sequence-specific oligonucleotides) vedla k unikátnímu modelu, který nebyl popsaný u žádné se známých alal. PCR-SSP na 4 desetinná místa neoznačila žádnou se známých B*44 allele. Sekvence HLA-B lokusu odhalila novou B*4442 allelu, která je identická s B*4405 a vede k C→G nukleotidové výměně v pozici 572. Tato nukleotidová záměna způsobuje substituci serinu za tryptofan v pozici 167 a expresi HLA-B proteinu. B21 serologická reaktivita nového produktu B*4442 alely byla potvrzena dalším serologickým panelem typizačního sera. Naše výsledky potvrdily, že přítomnost serinu v pozici 167 alfa-2 domény HLA-B prote (cs)
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| Title
| - A single amino acid exchange shifts the serological reactivity of the novel HLA-B*4442 allele product from HLA-B44 to HLA-B21.
- A single amino acid exchange shifts the serological reactivity of the novel HLA-B*4442 allele product from HLA-B44 to HLA-B21. (en)
- Záměna jedné aminokyseliny produktu HLA-B*4442 alely vede k posunu serologické aktivity od HLA-B44 k HLA-B21 (cs)
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| skos:prefLabel
| - A single amino acid exchange shifts the serological reactivity of the novel HLA-B*4442 allele product from HLA-B44 to HLA-B21.
- A single amino acid exchange shifts the serological reactivity of the novel HLA-B*4442 allele product from HLA-B44 to HLA-B21. (en)
- Záměna jedné aminokyseliny produktu HLA-B*4442 alely vede k posunu serologické aktivity od HLA-B44 k HLA-B21 (cs)
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| skos:notation
| - RIV/61989592:15110/06:00003151!RIV07-MZ0-15110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(NR9099), Z(MSM6198959205)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/06:00003151
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - International Journal of Immunogenetics
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Indrák, Karel
- Kriegová, Eva
- Mrázek, František
- Petřek, Martin
- Raida, Luděk
- Ambrůzová, Zuzana
- Fae, Ingrid
- Fisher, Gottfried F.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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