About: Apoptosis induced by N6-substituted derivatives of adenosine is related to intracellular accumulation of corresponding mononucleotides in HL-60 cells     Goto   Sponge   NotDistinct   Permalink

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  • The in vitro induction of apoptosis by N6-substituted derivatives of adenosine and adenine was investigated in HL-60 cells. Using reversed phase HPLC/MS analysis we demonstrated that both N6-substituted derivatives of adenosine and adenine are phosphorylated within cells to the monophosphate level. While N6-substituted derivatives of adenosine were phosphorylated by adenosine kinase and corresponding mononucleotides were produced in large quantities, N6-substituted derivatives of adenine were converted into the corresponding mononucleotides via the phosphoribosyl transferase pathway, which yielded 50-100 times lower amounts of the mononucleotides than the adenosine kinase pathway. Accordingly, N6-substituted derivatives of adenine were relatively inefficient inductors of apoptosis at the concentrations applied. Inhibitors of adenosine kinase that abrogated the formation of monophosphates from N6-substituted derivatives of adenosine completely prevented cells from going into apoptosis. These results co
  • The in vitro induction of apoptosis by N6-substituted derivatives of adenosine and adenine was investigated in HL-60 cells. Using reversed phase HPLC/MS analysis we demonstrated that both N6-substituted derivatives of adenosine and adenine are phosphorylated within cells to the monophosphate level. While N6-substituted derivatives of adenosine were phosphorylated by adenosine kinase and corresponding mononucleotides were produced in large quantities, N6-substituted derivatives of adenine were converted into the corresponding mononucleotides via the phosphoribosyl transferase pathway, which yielded 50-100 times lower amounts of the mononucleotides than the adenosine kinase pathway. Accordingly, N6-substituted derivatives of adenine were relatively inefficient inductors of apoptosis at the concentrations applied. Inhibitors of adenosine kinase that abrogated the formation of monophosphates from N6-substituted derivatives of adenosine completely prevented cells from going into apoptosis. These results co (en)
  • In vitro indukce apoptozy N6-substitouvanými deriváty adenosinu a adeninu byla zkoumána u buněk linie HL-60. (cs)
Title
  • Apoptosis induced by N6-substituted derivatives of adenosine is related to intracellular accumulation of corresponding mononucleotides in HL-60 cells
  • Apoptosis induced by N6-substituted derivatives of adenosine is related to intracellular accumulation of corresponding mononucleotides in HL-60 cells (en)
  • Apoptoza indukovaná N6-substituovanými deriváty adenosinu je spojena s intracelulární akumulací korespondujících mononukleotidů u buněk HL-60 (cs)
skos:prefLabel
  • Apoptosis induced by N6-substituted derivatives of adenosine is related to intracellular accumulation of corresponding mononucleotides in HL-60 cells
  • Apoptosis induced by N6-substituted derivatives of adenosine is related to intracellular accumulation of corresponding mononucleotides in HL-60 cells (en)
  • Apoptoza indukovaná N6-substituovanými deriváty adenosinu je spojena s intracelulární akumulací korespondujících mononukleotidů u buněk HL-60 (cs)
skos:notation
  • RIV/61989592:15110/05:00001968!RIV06-MZ0-15110___
http://linked.open.../vavai/riv/strany
  • 985-990
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NC6652), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika
  • 7
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 512740
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/05:00001968
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cytokinins; phosphoribosyl transferase; adenosine kinase; cell death; TOBACCO BY-2 CELLS; LEUKEMIA-CELLS; INDUCTION; DEATH; DIFFERENTIATION; METABOLISM; ACTIVATION; PROTEASES; KINASE (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [F2CF92613045]
http://linked.open...i/riv/nazevZdroje
  • Toxicology in Vitro
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 19
http://linked.open...iv/tvurceVysledku
  • Doležel, Petr
  • Mlejnek, Petr
http://linked.open...n/vavai/riv/zamer
issn
  • 0887-2333
number of pages
http://localhost/t...ganizacniJednotka
  • 15110
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