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| Description
| - Heat shock proteins (hsp) were identified in many infectious agents as immunodominant antigens with a protective effect. Immunization of laboratory animals by selected representants of hsp60, hsp70 and hsp90 isolated from several pathogens induced protective host immunity and significantly reduced clinical manifestation of infection. The present study involves preparation of a recombinant protein vaccine and a DNA vaccine. Both vaccines were derived from the hsp60 of the dermatophyte, Trichophyton mentagrophytes. Challenge trials with evaluation of the protective effect of vaccination were performed on calves and guinea-pigs. Both vaccination procedures reduced, in statistically significant fashion, the clinical course of skin mycosis in calves experimentally inoculated with the dermatophyte, T. mentagrophytes. In experiments with guinea-pigs, increased protection was only seen with DNA vaccination. After DNA vaccine application, no paravaccination sideeffects (granulomas at the injection
- Heat shock proteins (hsp) were identified in many infectious agents as immunodominant antigens with a protective effect. Immunization of laboratory animals by selected representants of hsp60, hsp70 and hsp90 isolated from several pathogens induced protective host immunity and significantly reduced clinical manifestation of infection. The present study involves preparation of a recombinant protein vaccine and a DNA vaccine. Both vaccines were derived from the hsp60 of the dermatophyte, Trichophyton mentagrophytes. Challenge trials with evaluation of the protective effect of vaccination were performed on calves and guinea-pigs. Both vaccination procedures reduced, in statistically significant fashion, the clinical course of skin mycosis in calves experimentally inoculated with the dermatophyte, T. mentagrophytes. In experiments with guinea-pigs, increased protection was only seen with DNA vaccination. After DNA vaccine application, no paravaccination sideeffects (granulomas at the injection (en)
- Proteiny tepelného šoku (hsp) byly popsány u několika infekcí jako imunodomonantní antigeny s protektivním efektem. Imunizace laboratorních zvířat vybranými zástupci hsp60, hsp70 a hsp90 izolovanými z z několika patogenů indukovaly po vakcinaci protektivní imunitní odpověď a významně redukovaly klinické projevy infekce. Studie představuje přípravu rekombinantního hsp60 a odpovídající DNA vakcínu. Oba vakcinační hsp60 jsou odvozeny od dermatofyta Trichophyton mentagrophytes. Vakcinační experimenty spojené s čelenžním experimentem byly provedeny na modelech trichofytózy experimentálních telat a morčat. Oba postupy významně redukovaly průběh navozené kožní dermatofytózy T. mentagrophytes. Na morčecím modelu byla potvrzena protektivita DNA vakcinačního postupu bez klinických známek postraních paravakcinačních projevů. Na modelu telat pouze vakcinace rekombinantním proteinem navodila zvýšení hladiny specifických sérových protilátek. Toto pozorování indikuje že specifické protilátky nejsou spojeny s navozen (cs)
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| Title
| - Recombinant protein and DNA vaccines derived from hsp60 Trichophyton mentagrophytes control the clinical course of trichophytosis in bovine species and guinea-pigs
- Recombinant protein and DNA vaccines derived from hsp60 Trichophyton mentagrophytes control the clinical course of trichophytosis in bovine species and guinea-pigs (en)
- Rekombinantní proteiny a DNA vakcíny derivované z hsp 60 Trichophyton mentagrophytes ovlivňují klinický průběh trichophytózy u krav a morčat (cs)
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| skos:prefLabel
| - Recombinant protein and DNA vaccines derived from hsp60 Trichophyton mentagrophytes control the clinical course of trichophytosis in bovine species and guinea-pigs
- Recombinant protein and DNA vaccines derived from hsp60 Trichophyton mentagrophytes control the clinical course of trichophytosis in bovine species and guinea-pigs (en)
- Rekombinantní proteiny a DNA vakcíny derivované z hsp 60 Trichophyton mentagrophytes ovlivňují klinický průběh trichophytózy u krav a morčat (cs)
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| skos:notation
| - RIV/61989592:15110/04:00006164!RIV09-MZ0-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(NI7538), Z(MSM 151100002)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/04:00006164
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - deoxyribonucleic acid vaccination; hsp60; trichophytosis; calf; guinea-pig (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Raška, Milan
- Weigl, Evžen
- Běláková, Jana
- Chumela, Josef
- Rybnikář, Alois
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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